氯吡格雷停药后存在的血小板功能反跳现象  

The Phenomena of Platelet Function Rebound after Clopidogrel Withdrawal

作　　者：张文斌[1] 张新霞[1] 

机构地区：[1]广东医学院附属福田人民医院心血管内科,广东深圳518000

出　　处：《医学综述》2011年第22期3467-3470,共4页Medical Recapitulate

摘　　要：对于急性冠状动脉综合征患者的治疗,除非有高出血风险,氯吡格雷应联合阿司匹林使用至少1年。但有部分患者停用氯吡格雷后发生的心血管不良事件,一些研究认为此现象与停用氯吡格雷后血小板功能反跳有关。在此对停用氯吡格雷后血小板聚集率增加的定义,血小板功能反跳现象与血小板聚集能力、炎性因子等之间的关系及延长使用或逐渐停用氯吡格雷能否预防此反跳现象的发生予以综述。Clopidogrel combined with aspirin should be used at least 1 year in patient with acute coronary syndrome unless there is high risk of bleeding.However,some research suggest that the adverse cardiovascular event happened after clopidogrel withdrawal have some connection with platelet function rebound.Here is to review the definition of enhancive platelet aggregation after clopidogrel withdrawal,the relationship between rebound phenomena and platelet aggregation,and inflammation factor;and if prolonging or tapered withdrawl of clopidogrel can solve the problem.

关 键 词：氯吡格雷停药 心血管不良事件 血小板功能 反跳现象 

分 类 号：R541.4[医药卫生—心血管疾病]