东莨菪碱和阿托品对小鼠胃肠运动抑制作用的研究  

Research on the function of scopolamine and atropine to depress the gastrointestinal motility in rats

作　　者：黄舒婷[1] 阮素红[1] 马强[1] 薄秀梅[2] 

机构地区：[1]徐州医学院 [2]徐州医学院机能学实验中心

出　　处：《齐齐哈尔医学院学报》2011年第20期3262-3263,共2页Journal of Qiqihar Medical University

摘　　要：目的探索东莨菪碱与阿托品抑制小鼠胃肠运动的差异以及两者的协同作用。方法将小鼠随机分为生理盐水组(Ns)、新斯的明组(Ne)、新斯的明+阿托品组(Ne+At)、新斯的明+东莨菪碱组(Ne+Sc)、新斯的明+阿托品+东莨菪碱组(Ne+At+Sc),每组12只。采用小鼠小肠炭末推进试验,观察各组药物引起小鼠的小肠推进亢进或抑制作用。结果 1)新斯的明+东莨菪碱组的小鼠小肠推进百分率(49.82±3.48)与新斯的明+阿托品组(53.27±11.61)无明显差别(P>0.05);2)东莨菪碱与阿托品联用组(33.65±3.03)比单独运用阿托品、东莨菪碱组的小肠推进百分率明显降低(P<0.01和P<0.05)。结论东莨菪碱与阿托品有协同抑制小鼠胃肠运动的作用。Objective To investigate the difference and synergetic effects between Scopolamine and Atropine on depressing the gastric peristalsis in rats. Methods To divide the rats into five groups at random,including the group of normal saline（Ns）;neostigmine metheylsulfate（Ne）;neostigmine metheylsulfate ＋ Atropine（Ne＋At）;neostigmine metheylsulfate ＋ Scopolamine（Ne＋Sc） and neostigmine metheylsulfate ＋ Atropine ＋ Scopolamine（Ne＋At＋Sc）.Each group consisted of 12 rats.Conducting mice small intestine carbon powder propulsion test experiment,and observing the positive or negative effect on SIP of rats caused by drugs of the four groups. Results 1）There was no significant difference in percentage of the rat＇s SIP between the group of（49.82±3.48）eostigmine metheylsulfate injection with Atropine and（53.27±11.61）neostigmine metheylsulfate injection with Scopolamine（P0.05）.2）The group combining Scopolamine with Atropine（33.65±3.03）had a considerable reduction in percentage in comparison with the group applying Atropine or Scopolamine individually（P0.01 and P0.05）. Conclusions Scopolamine and Atropine have synergetic effect on depressing gastrointestinal motility.

关 键 词：胃肠运动 东莨菪碱 阿托品 

分 类 号：R971.92[医药卫生—药品]