8-羟基喹啉-2-醛缩芳香酰肼Ni(Ⅱ)配合物的合成及表征  

Ni(Ⅱ)complexes derived from 8-hydroxyquinoline-2-carboxaldehyde and aroylhydrazines

作　　者：张克钧[1] 刘永春[1] 胡怀生[1] 武芸[1] 赵俊英[1] 

机构地区：[1]陇东学院化学化工学院,甘肃庆阳745000

出　　处：《化学研究与应用》2011年第11期1461-1465,共5页Chemical Research and Application

基　　金：甘肃省教育厅研究生导师项目计划(1010B-04)资助

摘　　要：合成并表征了8-羟基喹啉-2-醛缩苯甲酰肼、8-羟基喹啉-2-醛缩水杨酰肼以及8-羟基喹啉-2-醛缩对羟基苯甲酰肼Ni(Ⅱ)配合物,并利用黏度滴定、紫外光谱和荧光光谱法研究了它们与CT-DNA相互作用情况。结果表明,这些配合物均为良好的DNA插入试剂,它们与DNA的结合常数(Kb)分别为1.006×105 M-1、9.154×105 M-1和2.663×105 M-1。Ni（Ⅱ）complexes,derived from 8-hydroxyquinoline-2-carboxaldehyde-（benzoyl）hydrazone（2a）,8-hydroxyquinoline-2-carboxadehyde-（o-hydroxybenzoyl）hydrazone（2b）and 8-hydroxyquinoline-2-carboxadehyde-（p-hydroxybenzoyl）hydrazone（2c）,were synthesized and characterized,respectively,then the interaction of complexes with ct-DNA were studied by viscosity titration,Ultraviolet-visible（UV-vis）spectroscopy and fluorescence spectroscopy.The experimental results indicate that all of the complexes are of good intercalators for DNA and the binding constants（Kb）are 1.006×105 M-1,9.154×105 M-1 and 2.663×105 M-1,respectively.

关 键 词：Ni(Ⅱ)配合物 Shiff碱 小牛胸腺DNA(CT-DNA) DNA插入试剂 

分 类 号：O614.813[理学—无机化学]