反相微乳液制备pH响应型纳米水凝胶及其作为药物载体的研究  

pH-responsive nanogel prepared via inverse microemulsion polymerization as a drug carrier

作　　者：卫福苗[1] 毕红[1] 宋梦梦[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《安徽大学学报（自然科学版）》2011年第6期80-86,共7页Journal of Anhui University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(50772001);安徽大学"211工程";安徽大学杰出青年培育基金资助项目(KJJQ006);安徽大学学术创新团队资助项目

摘　　要：利用反相微乳液聚合,通过改变交联剂含量制备不同粒径的纳米水凝胶聚(甲基丙烯酸二甲氨基乙酯-co-甲基丙烯酸羟乙酯)(P(DMAEMA-co-HEMA)).纳米水凝胶的结构和形貌通过FT-IR、1H-NMR和TEM等进行了表征.利用紫外-可见分光光度计(UV)检测溶液在不同pH下的透光率,结果显示纳米水凝胶在酸性条件下有明显的溶胀现象.选取阿霉素(DOX)为模型药物研究了该纳米水凝胶作为药物载体的可行性,结果发现该纳米水凝胶能很好地负载药物,载药率达45.7%.利用紫外光谱法测定载药纳米水凝胶分别在pH 5.0和7.4的溶液中的药物释放行为,结果表明该纳米水凝胶具有较好的pH响应性,在酸性条件下纳米水凝胶的溶胀现象使得药物释放速率比在中性环境下快.Different sizes of nanogel P（DMAEMA-co-HEMA） have been prepared via inverse emulsion polymerization by changing the crosslinker contents.The structure and morphologies of the nanogel were characterized by FT-IR,1H-NMR and TEM.The optical transmittance of the solution was characterized by UV and the results demonstrated that there was an obvious swelling phenomenon of the nanogel under acidic conditions.In order to explore the possibility of the nanogel as a drug carrier and its pH responsive property,DOX was chosen as a model drug and the drug loading efficiency could reach 45.7%.The release behavior of the nanogels at pH of 5.0 and 7.4 monitored by UV spectroscopy revealed that the lower pH value triggered more rapid drug release rate than neutral medium,owing to the swelling of the nanogels.

关 键 词：PH响应 纳米水凝胶 P(DMAEMA-co-HEMA) 药物载体 

分 类 号：R944[医药卫生—药剂学]