胶原多肽基表面活性剂合成工艺的优化  

Optimization of Reaction Parameters for Synthesis of Collagen-Peptide Based Surfactant

作　　者：迟原龙[1] 崔敏[1] 廖学品[1] 张文华[1] 石碧[1] 

机构地区：[1]四川大学制革清洁技术国家工程实验室,四川成都610065

出　　处：《中国皮革》2011年第23期8-11,共4页China Leather

基　　金：863计划课题(SQ2010AA0621629001);国家科技支撑计划(2011BAC06B11)资助项目

摘　　要：采用碱性蛋白酶水解废弃皮屑提取胶原多肽,然后使其与油酰氯反应合成胶原多肽基表面活性剂。以胶原多肽的氨基转化率和油酰氯的效率值作为评价指标,考察反应温度和时间、油酰氯用量、丙酮用量、氢氧化钠用量和胶原多肽浓度的影响,进而确定合成胶原多肽基表面活性剂的优化工艺。试验结果表明:合成目标产物的优化条件为100mL质量浓度为10%的胶原多肽、30mmol/L油酰氯、10mL丙酮和60mmol/L氢氧化钠,先在30℃反应2h,再升温至60℃反应2h。在此条件下胶原多肽的氨基转化率为74.4%,油酰氯的效率值为1.21,合成产物的临界胶束浓度为0.66g/L,在此浓度下表面张力为35.85mN/m。The collagen peptide was prepared by digestion of tannery skin waste using alkaline protease. Then a collagen - peptide based surfactant （CBS） was synthesized by interaction between the collagen peptide and oleoyl chloride. The effects of reaction temperature and time, the contents of oleoyl chloride, acetone and sodium hydroxide, and collagen peptide concentration on the transfer ratio of peptide amino group and the reaction efficiency of oleoyl chloride were investigated. The results show that the optimized reaction conditions are as follows： 100mL 10% （w/v） collagen peptide, 30mmol/L oleoyl chloride, 10mL acetone and 60mmol/L sodium hydroxide react at 30℃ for 2h, and then 60℃ for 2h. The transfer ratio of peptide amino group and the reaction efficiency of oleoyl chloride under the optimized reaction conditions are 74.4% and 1.21, respectively. The critical micelle concentration （cmc） and surface tension at cmc of CBS are 0.66g/L and 35.85mN/m, respectively.

关 键 词：制革 废弃物 胶原 表面活性剂 合成工艺 

分 类 号：TS59[轻工技术与工程—皮革化学与工程]