红霉素对支气管上皮细胞转录因子c-Jun和核因子-κB表达的影响  

The effects of Erythromycin on c-Jun and nuclear factor-κB expression of bronchial epithelial cells

作　　者：于亮[1] 王梅[1] 袁军[1] 张利[1] 孟晓武[1] 鲍文韬[1] 贾健[1] 张莹[1] 吴鹏[1] 

机构地区：[1]山东省泰安市中心医院呼吸重症科,泰安271000

出　　处：《现代免疫学》2011年第6期499-502,共4页Current Immunology

摘　　要：探讨红霉素对4-羟基壬烯醛(4-HNE)引起的支气管上皮细胞(16-HBE)核转录因子c-Jun及NF-κB的影响。将人支气管上皮细胞分为4-HNE组(10μmol/L 4-HNE)红霉素+4-HNE组、对照组,在4-HNE刺激细胞2、4、8及12h后,检测c-Jun及NF-κB的变化。结果表明,4-HNE和对照组比较,c-Jun、NF-κB自2h后各时间段两组差异有统计学意义,P均<0.05。红霉素+4-HNE组在4-HNE刺激2h后,c-Jun及NF-κB的表达较4-HNE组,差异有统计学意义,P均<0.01。4-HNE促进支气管上皮细胞c-Jun及NF-κB的表达。红霉素可抑制4-HNE诱导的c-Jun及NF-κB的表达。To explore the effects of Erythromycin on the expression of c-Jun and nuclear transcription factor-κB induced by 4-hydroxynonyl（4-HNE） on bronchial epithelial cells（16-HBE）.The human bronchial epithelial cells divided into experimental group（10 μmol/L 4-HNE）,Erythromycin ＋4-HNE（Erythromycin incubation before 4-HNE stimulation） and control group,detected the expression of c-Jun and NF-κB after 4-HNE stimulated cells for 2 h,4 h,8 h and 12 h.The expression of c-Jun and NF-κB stimulation between the experimental group and control groups was statistically significant,P0.05.The difference of the c-Jun and NF-κB expression of the experimental were statistically significant between the groups with Erythromycin incubation before 4-HNE stimulation compared with 4-HNE groups,P0.01.4-HNE promote bronchial epithelial cells c-Jun and NF-κB expression.Erythromycin could inhibit 4-HNE-induced the expression of c-Jun an d NF-κB.

关 键 词：4-羟基壬烯醛 核转录因子(NF-κB) 红霉素 C-JUN 

分 类 号：O62[理学—有机化学] R73[理学—化学]