Influence of temperature and diffusive entropy on the capture radius of fly-casting binding  

作　　者：CHANG Le GUO XinLu ZHANG Jian WANG Jun WANG Wei 

机构地区：[1]National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China

出　　处：《Science China(Physics,Mechanics & Astronomy)》2011年第12期2237-2242,共6页中国科学：物理学、力学、天文学（英文版）

基　　金：supported by the National Basic Research Program of China (Grant No.2007CB814806);the National Natural Science Foundation of China (Grant Nos.10974088,10834002 and 10774069);the Natural Science Foundation of Jiangsu Province (Grant No.BK2009008)

摘　　要：The recognition and binding of proteins through the "fly-casting" mechanism are important biological processes. In this paper, a physical model for fly-casting binding is described based on the capillarity theory for protein chains. It is found that the capture radius for the fly-casting binding process is maximized at the transition temperature at which the free energy of the monomeric extended state of the protein equals that of the folded state. The factors related to the folding barrier or binding affinity do not change the condition needed to realize the optimization for fly-casting processes. These results will aid in the comprehensive understanding of binding processes.The recognition and binding of proteins through the ＂fly-casting＂ mechanism are important biological processes. In this paper, a physical model for fly-casting binding is described based on the capillarity theory for protein chains. It is found that the capture radius for the fly-casting binding process is maximized at the transition temperature at which the free energy of the monomeric extended state of the protein equals that of the folded state. The factors related to the folding barrier or binding affinity do not change the condition needed to realize the optimization for fly-casting processes. These results will aid in the comprehensive understanding of binding processes.

关 键 词：protein binding fly-casting mechanism protein folding 

分 类 号：O316[理学—一般力学与力学基础] TK403[理学—力学]