结核分枝杆菌的耐药基因及其相关分子机制  

The mycobacterium tuberculosis resistance genes and their molecular mechanism of drug resistance

作　　者：伍静[1] 师长宏[1] 

机构地区：[1]第四军医大学实验动物中心,陕西西安710032

出　　处：《现代生物医学进展》2011年第22期4382-4385,共4页Progress in Modern Biomedicine

基　　金：国家"863"专项课题(2007AA02Z473);国家自然科学基金(NO.30972769)联合资助

摘　　要：结核分枝杆菌原发性和继发性耐药是当前控制和治疗结核病面临的重要问题,随着分子遗传学的发展,已经阐明了结核分枝杆菌耐药的分子基础是染色体的突变,影响了药靶本身或激活了药物前体的细菌酶,造成MTB的耐药。本文主要就MTB对其常用药物的耐药机制展开讨论,以便正确认识MTB对不同药物的耐药机制,建立快速检测耐药结核分枝杆菌基因型的分子生物学方法。The important issues of the current control and treat TB is primary and secondary drug resistance, Along with the development of molecular genetics, Have expound that the molecular basis of Mycobacterium tuberculosis drug resistance is due to the chromosome mutation And affecting the drug target itself or activated the premise of bacterial enzymes. Cause the MTB drug resistance. This paper mainly for its are commonly used drugs MTB discuss drug-resistant mechanism and correctly understanding of different drugs MTB resistance mechanism, and Establishing a rapid detection drug-resistant Mycobacteria tuberculosis genotype molecular biological detection method.

关 键 词：结核分枝杆菌 耐药 分子机制 耐药基因 

分 类 号：Q93[生物学—微生物学] R3[医药卫生—基础医学]