金刚烷直接氧化制备金刚烷多元醇新工艺  

A novel synthesis of adamantane polyhydric alcohols by direct oxidation of adamantane

作　　者：付长安[1] 郭建维[1] 刘卅[2] 崔英德[1] 杨楚芬[1] 彭进平[1] 崔亦华[1] 

机构地区：[1]广东工业大学轻工化工学院,广东广州510006 [2]华南理工大学材料科学与工程学院,广东广州510640

出　　处：《化工学报》2011年第12期3428-3433,共6页CIESC Journal

基　　金：番禺科技计划项目(2009-z-40-1);广东工业大学重大培育专项(405095220)~~

摘　　要：引言 金刚烷（三环[3,3,1,1]^3.7癸烷）是一种周正对称、高度稳定的笼状饱和烃，它的4个桥头碳上的氢具有较强的化学反应能力，可以被选择性地取代引入相同或不同的基团，这使得分子的可设计性很强，被称为新一代精细化工原料。Adamantane polyhydric alcohols are important active intermediates for synthesis of adamantanebased specific medicines, fine chemicals and functional materials. In this paper, three adamantane polyhydric alcohols, including adamantane-1,3-diol, adamantane-1,3,5-triol and adamantane-1,3, 5,7- tetraol were synthesized via one-step oxidation reaction of adamantane by using Cr （Ⅵ） reagents as oxidants, acetic acid as solvent under the mild conditions. The structures of adamantane-1, 3-diol, adamantane-1,3,5-triol and adamantane-1,3,5,7-tetraol were confirmed by IR, ^1H NMR and element analysis. Influences of synthesis conditions on the oxidation reaction were investigated. The reaction mechanism of adamantane oxidation by Cr （Ⅵ） reagents was discussed as well. Under the optimum conditions, adamantane-1, 3-diol, adamantane-1, 3, 5-triol and adamantane-1, 3, 5, 7-tetraol could be synthesized with the yields of 71%, 42% and 35% respectively. Such synthesis technology for adamantane polyhydric alcohols is of potential for application because of brief reaction, convenient manipulation, and the mild conditions and so on.

关 键 词：金刚烷 氧化 金刚烷多元醇 

分 类 号：TQ031[化学工程] TQ203.5