去乙酰化酶的功能及其在体育科学中的应用  

Functions of sirtuins and their applications in sports science

作　　者：李方晖[1] 曹伟[1] 赵军[1,2] 刘承宜[1] 郝选明[1] 

机构地区：[1]华南师范大学激光运动医学实验室和民族健康与体质研究中心,广东广州510006 [2]暨南大学体育部,广东广州510630

出　　处：《体育学刊》2011年第6期138-144,共7页Journal of Physical Education

基　　金：国家自然科学基金资助项目(60878061);广东省自然科学基金资助项目(9151063101000059)

摘　　要：Sirtuins(SIRTs)是依赖于烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleo-tide,NAD+)的去乙酰化酶。除了对染色质组蛋白赖氨酸残基去乙酰化实现对基因的表观遗传修饰外,SIRT1可以调节多种关键转录调节因子及辅因子活性。SIRTs所介导的生理过程包括控制氧化应激响应、能量内稳态控制和运动代谢适应等。体育活动对代谢性疾病的预防或对衰老的延缓可能与SIRTs活性密切相关。多种运动训练方式和补充SIRTs小分子活性物质都能提高骨骼肌、脂肪、心肌和脑等脏器的SIRTs活性,提升机体抗疲劳及能量代谢适应的能力。SIRTs可能是表征功能内稳态的潜在标志物。Sirtuins（SIRTs） are nicotinamide adenine dinucleotide（NAD＋） dependent deacetylases.Besides realizing epigenetic modification on genes via the deacetylation of lysine residues in chromatin histones,SIRT1 can regulate the activity of several critical transcription regulating factors and cofactors.Physiological processes mediated by SIRTs include oxidative stress response control,energy homeostasis control and exercise metabolism adaptation.Physical exercises preventing metabolic diseases or delaying aging may be closely related to SIRTs activity.Various ways of sports training and supplementing SIRTs activating small molecule active substances can enhance the SIRTs activity of such organs as skeletal muscle,fat,cardiac muscle and brain,and boost the fatigue resistance and energy metabolism adaptation capacities of the body.SIRTs may be potential biomarkers that characterize functional homeostasis.

关 键 词：运动生物化学 去乙酰化酶 运动训练 功能内稳态 综述 

分 类 号：G804.7[文化科学—运动人体科学]