丙型肝炎患者生化变量与细胞因子间的相关性分析  

Correlation between biochemical indicators and cytokines in hepatitis C patients

作　　者：由莉越 迟淑萍[1] 汪辰 孙杰 周婷婷[2] 陈红鸽 赵庆国[1] 程云[1] 

机构地区：[1]解放军第三〇二医院药学部,北京100039 [2]军事医学科学院基础医学研究所,北京100850

出　　处：《中国医药导报》2011年第34期20-22,共3页China Medical Herald

摘　　要：目的:研究丙型肝炎病毒感染后血液生化变量与细胞因子重组人干扰素γ(interferon-γ,IFN-γ)、肿瘤坏死因子α(tumor necrosis factor,TNF-α)、重组人白介素10(interleukin-10,IL-10)之间的相关性。方法:以66例丙型肝炎患者为材料,利用统计学软件,分析丙型肝炎患者各生化指标之间及与3种细胞因子间的相关性。结果:①除球蛋白(GLO)与TNF-α在0.05置信水平上有较低相关性(r=-0.287,P=0.046)之外,各生化变量与各细胞因子之间无明显相关性。②各生化变量之间,丙氨酸氨基转换酶(ALT)与天门冬酸氨基转换酶(AST)有显著的相关性(r=0.869,P=0),做除法后(ALT/AST)相关性基本被消除,各变量之间存在微弱互相关性。③除IFN-γ与TNF-α之间存在弱相关性(r=0.448,P=0.009)之外,各炎症细胞因子之间无明显相关性。结论:各生化指标之间、3种炎症细胞因子之间、各生化变量与3种炎症细胞因子间的相关性均较差。Objective： To study the correlation between biochemical indicators and cytokines of interferon-γ（IFN-γ）, tu- mor necrosis factor （TNF-α, interleukin-10 （IL-10） in hepatitis C patients. Methods： 66 patients with hepatitis C were se- lected as the material, the statistical software was used to analyze the correlation between biochemical indicators and the three eytokines in the 66 patients. Results： （1）There was a lower correlation between GLO and TNF （r=-0.287, P=0.046）, all biochemical indicators and the cytokines had no significant correlation. （2）There was a significantly correlation between ALT and AST （r=0.869, P=0）. （3）There was a weak correlation between IFN-γand TNF-α （r=0.448, P=0.009）, there was no significant correlation among other cytokines. Conclusion： There are lower correlations not only in various biochemical indicators and in cytokines, but also between biochemical indicators and three eytokines.

关 键 词：丙型肝炎 细胞因子重组人干扰素γ 肿瘤坏死因子Α 重组人白介素10 

分 类 号：R512.63[医药卫生—内科学]