王浆酸的新合成方法  

A New Method for the Synthesis of Royal Jelly Acid

作　　者：黄林美[1] 刘慧燕[1] 刘玉珠[1] 杨秀仙[1] 许令娟[1] 宗乾收[1] 

机构地区：[1]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《嘉兴学院学报》2011年第6期100-103,共4页Journal of Jiaxing University

基　　金：浙江省大学生科研创新团队资助项目(2011R417017);浙江省高校优秀青年教师资助项目(00511024)

摘　　要：研究了以1,8-辛二醇为原料,用二氢吡喃作单边保护,在Tempo催化剂下用NaClO氧化,再与丙二酸发生kaoevenaglel反应来合成王浆酸的新路线.结果表明:该路线具有原料易得,各步反应条件温和,分离简单,路线短等特点,为王浆酸的新工业化生产提供了科学依据和理论基础.A new approach to synthesizing royal jelly acid （trans--10--hydroxy--2--decenoic acid） was investigated, including selective monoprotection of 1,8-octanediol by 2,3--dihydropyran, oxidiation of the primary alcohol to aldehyde by NaClO using Tempo as the catalyst, and finally Kaoevenaglel reaction with malonic acid, three steps in total to yield the product. All the starting materials are easily available and the reactions were carried out under mild conditions with easy separation and few steps, providing new scientific basis and theoretical basis for the industrial production of royal jelly acid.

关 键 词：1 8-辛二醇 kaoevenaglel 王浆酸 

分 类 号：O641.3[理学—物理化学]