针刺防治肿瘤患者化疗后周围神经毒性及消化道不良反应20例临床研究  

Effect of Acupuncture on Chemotherapy-related Peripheral Neurotoxicity and Digestive Tract Adverse Effects of Malignant Tumor Patients:A Clinical Study on 20 Cases

作　　者：侯海鲲[1] 程海英[2] 

机构地区：[1]北京积水潭医院针灸科 [2]首都医科大学附属北京中医医院

出　　处：《中医杂志》2011年第23期2031-2033,共3页Journal of Traditional Chinese Medicine

摘　　要：目的观察针刺疗法对化疗药物紫杉醇、奥沙利铂所致周围神经毒性及消化道不良反应的防治效果。方法将40例肿瘤患者随机分为针刺组和对照组各20例,两组均采用化疗方案及常规治疗,治疗组自化疗当日起取手足十二针穴位进行针刺治疗,每日1次,连续治疗2周。1个化疗周期后采用美国国立癌症研究院药物毒副作用评价标准(NCI标准)评价两组患者周围神经毒性、消化道不良反应的发生率及评分。结果周围神经毒性发生率两组均为60%,两组周围神经毒性发生率及评分比较差异均无统计学意义(P>0.05)。消化道不良反应发生率治疗组为70%,对照组为85%,两组比较差异无统计学意义(P>0.05);两组消化道不良反应评分比较差异有统计学意义(P<0.05),治疗组低于对照组。结论针刺可以减轻化疗药物所致消化道不良反应的严重程度,对周围神经毒性的影响尚需要大样本的研究。Objective To observe the preventive and therapeutic effect of acupuncture on the chemotherapy-related peripheral neurotoxicity and digestive tract adverse effects of malignant tumor patients induced by paclitaxel and oxaliplatin. Methods Forty malignant tumor patients were randomized into acupuncture group and control group with 20 in each. The two groups were treated with chemotherapy and routine medication. The acupuncture group was given acupuncture at the bilateral Quchi （LI11）, Neiguan （PC 6）, Hegu （LI 4）, Zusanli （ST 36）, Sanyijiao （SP 6） and Yanglingquan （GB 34 ） at the start of chemotherapy, once per day, 2 weeks in succession. After one course of chemotherapy, the National Cancer Institute （NCI） Common Toxicity Criteria Grading System Version 2.0 was adopted to evaluate the effect of treatment and score the incidence of the chemotherapy-related peripheral neurotoxicity and digestive tract adverse effects of the patients. Results The incidence of the chemotherapy-related peripheral neurotoxicity was 60% in both groups, the comparison between the two groups in the incidence and score showed no statistical difference （P0.05）. The incidence of digestive tract adverse effects in the acupuncture group was 70%, and that in the control group was 85%, the comparison between the two groups showed no statistical difference （P0.05）. The score of digestive tract adverse effects in the acupuncture group was lower than that in the control group, and the difference between the two groups was statistically significant （P0.05）. Conclusion Acupuncture can alleviate the severity of digestive adverse effects of chemotherapy, while its effect on the peripheral neurotoxicity needs further study with greater samples.

关 键 词：针刺 肿瘤 化疗 神经毒性 消化道不良反应 

分 类 号：R246[医药卫生—针灸推拿学]