Protis蛋白分析系统对肾脏早期损害的应用研究  

The applied study of Protis protein analysis system in early kidney damage

作　　者：伍柏青[1] 张志勇[1] 刘燕鸣[1] 陈会[1] 

机构地区：[1]江西省人民医院,江西南昌330006

出　　处：《实验与检验医学》2011年第5期486-488,496,共4页Experimental and Laboratory Medicine

基　　金：江西省卫生厅科技计划项目;编号20073008

摘　　要：目的探讨Protis蛋白分析系统在肾脏早期损害中的应用,对GFR进行评估。方法采用全自动生化分析仪检测分析血Crea、尿Crea、尿TP,全自动特定蛋白分析仪检测分析尿液中AlbI、gG、α1M、α2M以及血CysC,用尿液干化学仪器和显微镜作尿液常规;实验结果输入Protis蛋白系统生成图谱并进行分析。结果 301例患者和50例健康对照结果示:①血CysC,肾小管间质性肾病组、血尿伴混合性蛋白尿组明显高于健康对照组;②尿Alb各患者组均明显高于健康对照组,尤以肾病综合征组最高;③尿α1M各组均明显高于对照组,以肾病综合征组最高;④尿α2M肾后性血尿组明显增高。结论利用Protis蛋白分析系统能对蛋白尿进行分类能较好地评估病情及肾脏的损害程度,并对肾性血尿和肾后性血尿进行鉴别诊断。Objective To explore the application of Protis protein analysis system in early renal damage and evaluate glomerular filtration rate（GFR）.Methods Serum creatine,urinal creatine,urinal total protein were detected by the automatic biometry analyser.Urinary Alb、IgG、α1M、α2M and serum cysC were detected by the automatic defenite protein analyser.Urine routine was detected by chemical analyzer and microscope.All results were analyzed using Protis protein system generation atlas.Results The comparative results of 301 patients and 50 healthy controls demonstrate： ①Serum cysteine of tubulointerstitial nephropathy and bloody urine mixed albuminuria group were significantly higher than that of healthy group;②Urinary Alb of all disease groups were higher than that of the controls;③Urinary α1M of all disease groups was higher than that of healthy group,it showed the highest in nephrotic syndrome group;④Urinary α2M in postrenal group increased significantly.Conclusions Pathogenetic condition and renal damage,renal and postrenal bloody urine can be identified by using Protis protein analysis system.

关 键 词：Protis蛋白分析系统 慢性肾脏疾病 蛋白尿 血尿 

分 类 号：R446.112[医药卫生—诊断学] R446.121[医药卫生—临床医学]