星形聚乙二醇-聚乳酸嵌段共聚物的合成与表征  

Synthesis and Characterization of Multi-Arm Star-Shaped Poly(Ethylene Glycol)-b-Poly(L-Lactide) Copolymer Prepared by Ring-Opening Polymerization

作　　者：张安强[1] 林雅铃[2] 魏芬芬[1] 王炼石[1] 

机构地区：[1]华南理工大学材料科学与工程学院,广东广州510641 [2]华南农业大学资源与环境学院,广东广州510642

出　　处：《高分子材料科学与工程》2011年第11期84-88,共5页Polymer Materials Science & Engineering

基　　金：广东省自然科学基金资助项目(07300675);广东省高性能与功能高分子材料重点实验室开放基金资助项目;华南农业大学校长基金新学科扶持基金项目;华南农业大学资源环境学院院长基金项目

摘　　要：以不同臂数和分子量的星型聚乙二醇(sPEG)和L-丙交酯为原料,采用开环聚合法合成了以星型聚乙二醇为内部嵌段、聚L-乳酸为外部嵌段的多臂星形聚乙二醇-聚乳酸嵌段共聚物(sPEG-b-PLLA)。研究了sPEG的臂数、分子量及L-丙交酯/sPEG投料比等参数对产物结构与性能的影响。并分别用红外光谱(FT-IR)、核磁共振(1H-NMR)、凝胶渗透色谱(GPC)、差示扫描量热(DSC)对产物进行了表征,证实所合成的嵌段共聚物具有预期的结构。结果表明,sPEG-b-PLLA为结晶性聚合物,且表现出与PLLA相似的晶型,随着PLLA链段的增加,产物的结晶度也呈增大的趋势;与PLLA相比,sPEG-b-PLLA的接触角随着PEG链段的增多而增大,表明其亲水性明显改善。Biodegradable,amphiphilic,diblock multi-arm star-shaped poly（ethylene glycol）-block-poly（L-lactide） copolymer（sPEG-b-PLLA） were prepared by ring-opening polymerization of L-lactide in the presence of multi-arm sPEG and a catalytic amount of stannous octoate,in which three types of sPEG,i.e.,sPEG1（4-arm,n=4300）,sPEG2（3-arm,n=3200） and sPEG3（4-arm,n=12400） were chosen as the core of the block copolymer.The polymers,including sPEG and sPEG-b-PLLA copolymers with varied core and varied lactide/sPEG ratios were characterized and confirmed by 1H nuclear magnetic resonance spectrum（1H-NMR）,Fourier transform infrared spectrum（FT-IR） and gel permeation in chromatography（GPC）.The results showed that a serial of sPEG-b-PLLA copolymers with expected structures are successfully prepared.X-ray diffraction（XRD） results show that the sPEG-b-PLLA copolymers have similar crystal structure as that of PLLA,and its crystallinity is improved with the increase of PLLA segments.Contact angle testing shows that compared with linear PLLA,the hydrophilic properties of sPEG-b-PLLA are distinctly improved with the increase of PEG segments.

关 键 词：星形聚乙二醇-聚乳酸嵌段共聚物 星型聚乙二醇 开环聚合 

分 类 号：TQ316.344[化学工程—高聚物工业]