利用ROC曲线分析sTREM-1、PCT和CRP对多发伤早期感染的诊断价值  

Diagnosis value of ROC Curve analysis on sTREM-1,PCT and CRP for patients with multiple injury early infection

作　　者：徐志康[1] 陈望[1] 刘和录[1] 刘镇平[1] 华建江[1] 赖剑波[2] 朱兆钧[1] 汪奇云[1] 

机构地区：[1]广州医学院附属深圳沙井医院检验科,广东深圳518104 [2]广州医学院附属深圳沙井医院中心ICU,广东深圳518104

出　　处：《中国实验诊断学》2011年第11期1885-1887,共3页Chinese Journal of Laboratory Diagnosis

基　　金：深圳市科技计划资助项目(201002150)

摘　　要：目的利用ROC曲线分析血清可溶性髓样细胞触发受体-1(sTREM-1)、降钙素原(PCT)和C反应蛋白(CRP)对多发伤患者早期感染的诊断价值。方法测定57例ISS评分≥16分的多发伤患者血清sTREM-1、PCT和CRP含量,并与对照组进行比较,应用受试者工作特征曲线(ROC)进行分析。结果与对照组相比,多发伤早期未并发感染和并发感染的患者血清sTREM-1、PCT和CRP均呈不同程度升高(P均<0.01);与非感染组相比,并发感染患者血清sTREM-1和PCT仍呈不同程度升高(P均<0.01),而CRP在两组之间无显著差异(P>0.05);sTREM-1、PCT和CRP的ROC曲线下面积分别为0.954,0.863和0.785;最佳阀值分别为8.96 ng/ml,8.29 ng/ml,67.95 mg/L;灵敏度分别为0.912、0.787和0.938;特异度分别为0.894、0.845和0.513。结论血清sTREM-1是严重多发伤患者早期感染较好的辅助诊断指标,其诊断性能明显优于PCT和CRP。Objective Discuss the value of using ROC Curve to analyze soluble triggering receptors expressed on myeloid cells-1（sTREM-1）,Procalcitonin（PCT） and C reactive protein（CRP） for the diagnosis of patients with multiple injury earyly infection.Methods Evaluate the serum sTREM-1,PCT and serum CRP level of the 57 patients with multiple injury whose ISS score≥16.Comparing with the control group,analyze the result by ROC method.Results Compare to the control group,the multiple injuries patients with early infection and that without early infection,their serum sTREM-1,PCT and CRP level increased（P〈0.01）.Compare to the patient without infection,the sTREM-1,PCT level of the patients with infection also increased（P〈0.01）,but the CRP level remained the same（P〈0.05）.The sTREM-1,PCT and CRP area under the ROC curve are 0.954,0.863 and 0.785;best threshold are 8.96 ng/ml,8.29 ng/ml,67.95 mg/L;sensitivity are 0.912,0.787,0.938;specifity are 0.894,0.845,0.513.Conclusion Serum sTREM-1 is a better diagnostic marker of early infection for severe multiple injury patients,whose diagnostic performance is significantly better than PCT and CRP.

关 键 词：ROC曲线 STREM-1 PCT CRP 多发伤 早期感染 

分 类 号：R641[医药卫生—外科学]