Plasma Vitamin D Levels And Vitamin D Receptor Polymorphisms Are Associated with Survival of Non-small Cell Lung Cancer  

作　　者：Yao Liu Wei Chen Zhi-bin Hu Lin Xu Yong-qian Shu Shi-yang Pan Jun-cheng Dai Guang-fu Jin Hong-xia Ma Hong-bing shen 

机构地区：[1]Department of Epidemiology and Biostatistics, School of Public Heolth, Nonjing Medical University, Nanjing 210029, China [2]Department of Thoracic Surgery, Jiengsu Cancer Hospital, Nanjing, China [3]Department of Oncology, Jiangsu Key Discipline of Medicine, the First Affiliated Hospital, Nanjing Medical University,Nanjing, China [4]Department of Laboratory Diagnosis, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China [5]Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing, China

出　　处：《Chinese Journal of Cancer Research》2011年第1期33-37,共5页中国癌症研究（英文版）

基　　金：supported in part by Key Grant of the National Natural Science Foundation of China (No. 30730080);National Natural Science Foundation of China (No. 30972541, 30901233);National Outstanding Youth Science Foundation of China (No. 30425001);Key Laboratory of Laboratory Mecicine of Jiangsu Province (No. XK200731)

摘　　要：Objective：Vitamin D and its receptor（VDR） involve in multiple cellular processes and play an important role in the initiation and progression of malignancy.Thus we hypothesized that plasma vitamin D levels and single nucleotide polymorphisms（SNPs） in VDR may be of prognostic significance in non-small cell lung cancer（NSCLC）.Methods：We examined plasma 25-hydroxyvitamin D [25（OH）D] levels in 87 patients diagnosed with NSCLC using enzyme-linked immunosorbent assay（ELISA） and genotyped seven potentially functional SNPs in VDR in 568 NSCLC patients on Illumina Golden Gate platform.Results：Patients with higher plasma 25（OH）D levels had worse survival than patients with lower ones（P for trend = 0.048）.The SNPs of rs1544410 and rs739837 were independently associated with NSCLC survival（adjusted HR = 1.61,95% CIs = 1.06-2.45 for rs739837 AA vs AC/CC and adjusted HR = 1.51,95% CIs = 1.06-2.16 for rs1544410 AG/AA vs GG）.A joint effect was observed between rs1544410 and rs739837 and the risk of death elevated as the number of unfavourable genotypes patients carried increased（P for trend = 0.003）.There were no significant associations between VDR polymorphisms and plasma 25（OH）D levels.Conclusion：Our findings indicate that plasma 25（OH）D levels and genetic variants of VDR may serve as prognostic markers for NSCLC in this Chinese population.Objective：Vitamin D and its receptor（VDR） involve in multiple cellular processes and play an important role in the initiation and progression of malignancy.Thus we hypothesized that plasma vitamin D levels and single nucleotide polymorphisms（SNPs） in VDR may be of prognostic significance in non-small cell lung cancer（NSCLC）.Methods：We examined plasma 25-hydroxyvitamin D [25（OH）D] levels in 87 patients diagnosed with NSCLC using enzyme-linked immunosorbent assay（ELISA） and genotyped seven potentially functional SNPs in VDR in 568 NSCLC patients on Illumina Golden Gate platform.Results：Patients with higher plasma 25（OH）D levels had worse survival than patients with lower ones（P for trend = 0.048）.The SNPs of rs1544410 and rs739837 were independently associated with NSCLC survival（adjusted HR = 1.61,95% CIs = 1.06-2.45 for rs739837 AA vs AC/CC and adjusted HR = 1.51,95% CIs = 1.06-2.16 for rs1544410 AG/AA vs GG）.A joint effect was observed between rs1544410 and rs739837 and the risk of death elevated as the number of unfavourable genotypes patients carried increased（P for trend = 0.003）.There were no significant associations between VDR polymorphisms and plasma 25（OH）D levels.Conclusion：Our findings indicate that plasma 25（OH）D levels and genetic variants of VDR may serve as prognostic markers for NSCLC in this Chinese population.

关 键 词：Vitamin D receptor polymorphisms Non-small cell lung cancer Chinese population PROGNOSIS 

分 类 号：Q565[生物学—生物化学] S852.43[农业科学—基础兽医学]