绝经与中国南方地区女性代谢综合征的关系  

The relationship between menopause and metabolic syndromes in women in southern China

作　　者：陈冬梅[1] 彭谨[1] 李春花[1] 刘颖[1] 谢梅青[1] 

机构地区：[1]中山大学孙逸仙纪念医院妇产科,广州501120

出　　处：《中国骨质疏松杂志》2011年第11期945-950,共6页Chinese Journal of Osteoporosis

基　　金：广东省科技计划基金(2009B060300019)

摘　　要：目的了解中国南方地区40～70岁女性代谢综合征(metabolic syndrome,Mets)与绝经的关系。方法 913例40～70岁女性,按照不同绝经阶段进行分组,根据国际糖尿病联盟(IDF)全球代谢综合征工作定义标准,分析不同绝经阶段Mets各代谢异常的组分的患病率及与绝经的关系。结果 (1)本研究观察例数为913例,研究对象的平均年龄为51.51±6.10岁,平均初潮年龄为14.08±3.10岁,平均绝经年龄为49.71±3.92岁;(2)总体研究对象的Mets的患病率为27.82%,绝经后女性的Mets的患病率为35.48%。不同绝经阶段女性的Mets的患病率存在差异,从绝经过渡期晚期Mets的患病率显著增加(P<0.01);(3)总体研究对象中心性肥胖及高甘油三脂血症的患病率随着绝经年限及年龄的增加而增加(χ2=19.25,P=0.002,χ2=29.96,P<0.001),患病率分别为58.38%,28.92%。(4)同年龄阶段绝经女性较未绝经女性Mets的患病率增加(χ2=73.52,P<0.001);(5)Mets的相关影响因素的Logistic回归分析的结果显示绝经与Mets显著相关(OR=1.24,95%CI=1.003-1.450,P=0.002)。结论中国南方地区40～70岁女性Mets的患病率为27.82%,绝经后女性Mets的患病率为36.48%。绝经后女性是Mets的高危人群,绝经是Mets的危险因素。绝经过渡期晚期是Mets患病率显著升高的最早时期,故可将绝经过渡期晚期作为防止Mets的"窗口期"。Objective To investigate the relationship between menopause and metabolic syndromes （Mets） in women of 40- 70 years old in southern China. Methods Nine hundred and thirteen women of 40 -70 years old were divided into groups according to different menopausal period. The relationship between the prevalence of Mets with different menopausal status and menopause was analyzed according to IDF criteria. Results （1） The number of observation cases of this study was 913. The mean age of the subjects was 51.51 ：t： 6. 10 years old. The mean age of menarche was 14.08 -＋ 3. l0 years old. The mean age of menopause was 49.71 ＋3. 922 years old. （2） The prevalence of Mets in total subjects was 27.82%. The prevalence of Mets in postmenopausal women was 36.48% . The prevalence of Mets differed in women of different menopause period. The prevalence of Mets increased in peri-menopausal and postmenopausal period （P 〈 0. 01 ）. （3） The prevalence of central type obesity and hyper increased with a increase of menopause time and aging （X2 = 19.25,P = 0. 002 ,X2 = 29.96 ,P 〈 0. 001 ） in all subjects, The prevalence was 58. 38% and 28.92% , respectively. （4） The prevalence of Mets in postmenopausal women increased comparing to non- menopausal women at the same age （X2 -= 73.52,P 〈 0. 001 ）. （5） The Logistic regression analysis of relative risk factors for Mets showed that the Mets was associated with menopause significantly （OR = 1.24, 95% CI = 1. 003 - 1. 450, P = 0. 002）. Conclusion The prevalence of Mets is 27.82% in women of 40 - 70 years old in southern China, 36. 48% in the postmenopausal women. Postmenopausal women are at high-risk of Mets. Menopause is a risk factor for Mets. Late peri-menopause period is the earliest period of increased risk of Mets. The perimenopause period can be considered as window period for the prevention of Mets.

关 键 词：绝经 代谢综合征 

分 类 号：R336[医药卫生—人体生理学]