诱发负性情绪对健康人群心脏自主神经活动的影响  

Effect of negative emotion evocation on autonomic function activity of hearts in healthy population:an empirical study

作　　者：刘韬[1] 邓光辉[2] 经旻[2] 

机构地区：[1]第二军医大学研究生管理大队,上海200433 [2]第二军医大学卫生勤务学系心理学教研室,上海200433

出　　处：《第二军医大学学报》2011年第11期1204-1207,共4页Academic Journal of Second Military Medical University

基　　金：第二军医大学大学生创新能力培养计划立项课题~~

摘　　要：目的研究负性情绪应激对健康人群心脏自主神经活动的影响,初步探讨负性情绪在冠心病发病过程中可能的作用机制。方法健康大学生69名,采用计算机游戏诱发负性情绪,采集皮电、心率和心率变异性(HRV)等生理指标,比较各阶段各项指标的差异。结果在预期阶段和应对阶段低频功率(LF)值上升[F(2,67)=5.620,P<0.01],高频功率(HF)值下降[F(2,67)=10.773,P<0.01],LF/HF比值上升[F(2,67)=40.327,P<0.01],表明被试者在应激任务中心脏交感-迷走神经活动产生了明显改变,表现为交感神经功能的相对兴奋及迷走神经功能的相对抑制,交感-迷走神经的不平衡性增加。结论健康个体暴露于负性情绪应激时,心脏自主神经功能产生与冠心病病理状态下相似的变化特征,提示长期的负性情绪应激可能是导致个体迷走神经功能受损的原因之一。Objective To study the effect of negative emotion evocation on the autonomic function activity of hearts in healthy subjects,and to initially discuss the mechanism by which negative emotion is involved in the development of coronary heart disease.Methods We selected 69 healthy university students as our subjects.A computer game was used to induce the stress among them;the skin code,heart rate and heart rate variability（HRV） were collected and compared at different phases.Results The high frequency（HF） value was significantly decreased（F=10.773,P0.01）,the low frequency（LF） value was significantly increased（F=5.620,P0.01）,and LF/HF ratio was significantly increased（F=40.327,P0.01） at both expecting phase and coping phase,which indicates significant changes of cardiac sympathovagal activity,including the relative excitation of sympathetic nerve,relative depression of the vagus nerve,and aggravated autonomic imbalance.Conclusion Exposure of healthy individual to acute emotional stress can induce autonomic variation similar to that of coronary heart disease,indicating that long-term negative emotional stress may be one of the risk factors for vagal dysfunction.

关 键 词：负性情绪 心率变异性 心脏 自主神经通路 

分 类 号：R541[医药卫生—心血管疾病]