泛耐药鲍氏不动杆菌喹诺酮类耐药相关基因研究  

Investigation of resistance-related genes to quinolones in pandrug-resistant Acinetobacter baumannii

作　　者：陈贤君[1] 梁军兵[1] 张春玲[1] 牛津[1] 郑蓓佳 

机构地区：[1]浙江省台州市中心医院检验科,浙江台州318000

出　　处：《中国卫生检验杂志》2011年第11期2788-2789,2792,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:调查泛耐药鲍氏不动杆菌喹诺酮类耐药相关基因的存在情况。方法:收集2008年1月-2008年12月住院患者标本中分离的泛耐药鲍氏不动杆菌共20株,采用聚合酶链反应(PCR)的方法分析6种喹诺酮类耐药相关基因。结果:20株泛耐药鲍氏不动杆菌均存在gyrA基因第83位TCA→TTA突变,其它5种基因均未检出。结论:本组20株泛耐药鲍氏不动杆菌耐喹诺酮类药物与gyrA突变和AdeABC外排泵相关。Objective：To investigate the distribution of resistance-related genes to quinolones in pandrug-resistant Acinetobacter baumannii（A.baumannii）.Methods： From January 2008 to December 2008,20 strains of pandrug-resistant A.baumannii isolated from inpatients were collected from a hospital in China.Then,6 kinds of resistance-related genes to quinolones were analyzed by PCR.Results： All 20 strains（100.0%） performed mutations at 83rd coden in gyrA： TCA→TTA.But other 5 kinds of genes were not detected.Conclusion： Mutations of gyrA and drug efflux pump AdeABC might play a role in resistance to quinolones in these 20 strains of pandrug-resistant A.baumannii.

关 键 词：鲍氏不动杆菌 喹诺酮类 GYRA 突变 泛耐药 

分 类 号：R378.99[医药卫生—病原生物学]