ABO血型不合对异基因外周血造血干细胞移植后红系重建的影响  

Effect on erythrocyte reconstitution following ABO-incompatible aHogeneic peripheral blood stem cell transplantation

作　　者：谢宁[1,2] 符粤文 喻凤宽 房佰俊 张莉 周健 魏旭东 宋永平 

机构地区：[1]郑州大学附属肿瘤医院血液科,453003 [2]郑州大学第一附属医院血液科

出　　处：《白血病．淋巴瘤》2011年第11期666-668,共3页Journal of Leukemia & Lymphoma

摘　　要：目的观察ABO血型不相合异基因外周血造血干细胞移植（allo—PBSCT）后红系造血重建的特点。方法接受allo-PBSCT患者，分为ABO血型不合及相合两组，分别为65和72例，比较两组红系造血恢复特点；对于ABO血型不合组，比较血型主要不合（32例）、次要不合（23例）及主次均不合（10例）对移植后红系造血恢复的影响。结果ABO血型主次均不相合者较相合者红系造血恢复慢，分别为（97．9±10．4）d和（73．2±10.3）d，差异有统计学意义（P〈0．05）。不同类型血型不合移植患者血型转变时间分别为：主要不相合组（45．7±17．3）d、次要不相合组（41．2±16．1）d、均不相合组（48．4±20．9）d，差异无统计学意义（P〉0．05）。8例患者血型转变延迟，其中6例患者自身有抗．A抗体。结论ABO血型不相合不影响移植的疗效，其中主次均不合者红系造血恢复慢，自身有抗-A抗体的次要不合移植血型转变相对延迟。Objective To investigate the clinical characteristics in ABO-incompatible allogeneic peripheral blood stem cell transplantation （allo-PBSCT）. Methods 137 patients＇ clinical courses who accepted allo-PBSCT were retrospectively reviewed. Sixty-five cases of them were ABO-incompatible allo-PBSCT patients, including 32 ABO major mismatched cases, 23 ABO minor mismatched cases and 10 ABO major and minor mismatched cases. Seventy-two ABO-identical cases were taken as control group. Results Compared with ABO-idential cases, the time of erythrocyte recovery after allo-PBSCT in ABO major and minor mismatched group was delayed [（73.2±10.3） d vs （97.5±10.4） d] （P 〈0.05）. In ABO-incompatible group, the time of blood type switching in different ABO-incompatible types were found no significant difference （P 〉0.05） [ABO major mismatched： （45.7±17.3） d, ABO minor mismatched： （41.2±16.1） d and ABO major and minor mismatched： （48.4±20.9） d （P 〉 0.05）]. There were 8 cases who have a delayed time of blood type changing, including 6 cases demonstrated recipient-derived anti-A antibody. Conclusion ABO- incompatible has no negative effect on allo-PBSCT. The time of erythrocyte reconstitution was delayed in ABO major and minor mismatched group. A delayed time of blood type switching tends to occur in ABO minor incompatible cases and patients who have anti-A antibody initially.

关 键 词：血型不合 造血干细胞移植 血细胞生成 

分 类 号：R457[医药卫生—治疗学]