胱抑素C在急性肾损伤中的诊断价值  

THE DIAGNOSIS VALUE FOR CYSTATIN C IN ACTUE KIDNEY INJURY

作　　者：赵娟[1] 孟令权[2] 李冰冰[1] 史连义[3] 刘星[1] 张祎[1] 

机构地区：[1]中国石油天然气集团公司中心医院重症医学科,河北廊坊065000 [2]中国石油天然气集团公司中心医院骨科,河北廊坊065000 [3]中国石油天然气集团公司中心医院检验科,河北廊坊065000

出　　处：《河北医科大学学报》2011年第10期1120-1122,共3页Journal of Hebei Medical University

摘　　要：目的探讨胱抑素C在急性肾损伤(actue kidney injury,AKI)中的诊断价值。方法收集ICU患者141例,每例患者入ICU即刻及每天早晨留取血尿标本,检测血胱抑素C(serum cystatin C,scys C)、尿胱抑素C(urinarycystatin C,Ucys C)和血肌酐(serum creatinine,Scr)。结果 32例AKI患者较109例非AKI患者的Scys C、Ucys C、Scr均明显升高(P<0.05)。ROC分析证实,ScysC和UcysC在AKI诊断中的敏感性、特异性分别为78%、93%和81%、77%。结论胱抑素C可以作为重症患者并发AKI的诊断指标。Objective To study the diagnostic value of cystatin C in detecting actue kidney injury （AKI）. Methods A total of 141critically ill patients hospitalized in intensive care unit （ICU） were enrolled, blood and urinary samples were collected at admission and daily. Serum cystatin C （ScysC）, urinary cystatin C （UcysC） and serum creatinine （Scr） were detected. Results Cystatin C and creatinine in AKI patients were dramatically increased as compared to that of non - AKI. Receiver Operating Characteristic （ROC） analysis confirmed the sensitivity and specificity for ScysC and UcysC in AKI were 78% ,93% and 81% ,77% ,respectively. Conclusion Cystatin C can be used as a diagnostic marker of AKI in critically ill patients.

关 键 词：胱抑素C 急性肾损伤 诊断 

分 类 号：R692.5[医药卫生—泌尿科学]