两栖动物性别决定相关基因的研究进展  

Sex Determination-related Genes in Amphibians

作　　者：刘佳[1] 李忻怡[1] 张育辉[1] 

机构地区：[1]陕西师范大学生命科学学院,西安710062

出　　处：《动物学杂志》2011年第6期134-140,共7页Chinese Journal of Zoology

基　　金：国家自然科学基金项目(No.130770243)

摘　　要：两栖动物的性别决定机制主要包括遗传性别决定(genetic sex determination,GSD)和环境性别决定(environmental sex determination,ESD)。近年来,在两栖动物性别决定和性腺分化机制的研究中,运用分子生物学技术探讨性别决定相关基因及其相互关系方面的研究已获得新的成果。本文通过对DMRT1、DAX1、SF1、SOX3、SOX9、FOXL2、CYP19、CYP17在两栖动物性别决定中作用的分析,显示DAX1、SF1、FOXL2、SOX3均参与芳香化酶基因转录的调节,其中FOXL2、SOX3促进了CYP19的表达,DAX1、SF1则与CYP17的表达调节有关。这些结果提示,两栖动物性别决定相关基因通过作用于CYP19、CYP17的表达调控性别决定过程,基因和温度分别在GSD和ESD过程中通过影响雌、雄激素的水平而决定两栖动物性别。The sexual phenotype of amphibians is determined either by chromosomal factors（genetic sex determination,GSD）,or by environmental factors（environmental sex determination,ESD）.Recently,new findings on the sex determination-related genes and their interactions have obtained by utilizing molecular biology methods.Several genes such as DMRT1,DAX1,SF1,SOX3,SOX9,FOXL2,CYP19 and CYP17 have been found to play roles in determining the sexual phenotype of amphibians,with DAX1,SF1,FOXL2 and SOX3 involved in transcriptional regulation of aromatase gene.FOXL2 and SOX3 promote CYP19 expression.DAX1 and SF1 can influence CYP17 expression.Sex-determination genes play their roles by acting on the expression of CYP19 and CYP17.Both sex-determination related genes and temperature determine sex of amphibians by affecting estrogen and/or androgen levels.

关 键 词：两栖动物 性别决定 基因 温度 

分 类 号：Q953[生物学—动物学]