乙型肝炎病毒对超敏C反应蛋白表达的影响及其临床意义  

The effect of hepatitis B virus on the expression of high sensitive C-reaction protein and its clinicalimplication

作　　者：高国生[1,2] 朱海超[1,2] 胡爱荣[1,2] 徐晓珍[1,2] 

机构地区：[1]浙江省宁波市第二医院,315010 [2]宁波市传染病医院

出　　处：《中华微生物学和免疫学杂志》2011年第10期931-933,共3页Chinese Journal of Microbiology and Immunology

基　　金：宁波市自然科学基金（2010A610056）;吴阶平医学基金会肝病实验诊断研究基金（LDWMF-SY-2011C004）

摘　　要：目的探讨乙型肝炎病毒（HBV）对超敏C反应蛋白（hs-CRP）表达的影响及其临床意义。方法采用RT-PCR检测人肝癌细胞系HepG2和HepG2．2．15中hs-CRPmRNA的表达，通过Olympus5400全自动生化分析仪检测HBV患者和健康对照者hs-CRP血清学水平，分析hs-CRP在慢性乙型肝炎、肝硬化和肝癌患者中hs-CRP表达水平的差异。结果HepG2．2．15细胞中hs-CRPmRNA的表达水平较HepG2高；hs-CRP在乙肝感染者血清学水平屁著升高（P〈0．05）；hs-CRP在肝硬化患者和肝癌患者明显高于慢性肝炎患者。结论HBV能够上调hs-CRP的表达，其血清学水平与疾病进程相关。Objective To explore the effect of hepatitis B virus （HBV） on the expression of high sensitive C-reaction protein（hs-CRP） and its clinical implication. Methods mRNA expression of hs-CRP in HepG2 and HepG2.2.15 cells was measured by RT-PCR, serum hs-CRP levels in patients with HBV infection and in healthy individuals were measured by biochemical analyzer Olympus5400, the expression of hs-CRP difference among patients with chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma were analyzed. Results Expression of hs-CRP mRNA was higher in HepG2.2.15 ceils than in HepG2 cells, serum hs-CRP levels was much higher in HBV patients as compared to healthy individuals （ P〈0.05 ） , hs-CRP was detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with chronic hepatitis B. Conclusion HBV can upregulated the expression of hs-CRP, which is associated with the disease progression.

关 键 词：乙型肝炎病毒 超敏C反应蛋白 肝硬化 肝癌 

分 类 号：R51[医药卫生—内科学]