依达拉奉对破裂脑动脉瘤急性期夹闭术后脑血管痉挛和脑缺血的防治效果  

Efficacy of edaravone in treating postoperative vascular spasm and cerebral ischemia in patients with ruptured intracranial

作　　者：邹建华[1] 周岱[2] 崔岗[2] 

机构地区：[1]苏州大学附属第一医院药剂科,215006 [2]苏州大学附属第一医院神经外科,215006

出　　处：《江苏医药》2011年第22期2654-2655,共2页Jiangsu Medical Journal

摘　　要：目的观察依达拉奉在破裂脑动脉瘤急性期夹闭术后脑血管痉挛和脑缺血的疗效。方法破裂脑动脉瘤患者68例于发病后72h内施行动脉瘤夹闭术。术后随机分为两组,给予常规治疗;治疗组在对照组的治疗基础上加用依达拉奉2周。分别于术后1、3、7、14d用经颅多普勒超声(TCD)、头颅CT检查,术后3个月行格拉斯哥预后评分(GOS),评价疗效。结果治疗组第3、7天TCD测定的大脑中动脉血液流速明显低于对照组(P<0.05)。治疗组脑缺血的发生率明显低于对照组。治疗组总有效率88.5%,明显高于对照组的71.2%(P<0.05)。结论依达拉奉防治破裂颅内动脉瘤术后脑血管痉挛和脑缺血的效果明显。Objective To observe the efficacy of edaravone in treating postoperative vascular spasm and cerebral ischemia after early surgery for ruptured intracrania1 aneurysm. Methods Sixty-eight cases of ruptured intracranial aneurysm were treated with conventioal regime for two weeks after clipped within 72 hours.The patients were equally randomized into two groups of A（treted conventioally） and B（treated with additional edravone）.The efficacy was evaluated by transcranial Dopplar（TCD） and cerebral CT scan on the 1st, 3rd,7th and 14th day during treatment.GOS was performed three months later. Results The velocity of blood flow of the middle cerebral artery on the 3rd and 7th day was lower in group B than that in group A（P0.05）.The incidence of cerebral ischemia was lower in group B than that in group A. The total effectiveness rate was higher in group B than that in group A（88.5% vs.71.2%）（P0.05）. Conclusion Edaravone is effective in the treatment of postoperative cerebral vasospasm and cerebral ischemia in the patients with ruptured aneurysm.

关 键 词：依达拉奉 破裂脑动脉瘤 脑血管痉挛 脑缺血 

分 类 号：R971[医药卫生—药品]