甲型流感病毒分类与通用流感疫苗及广谱中和活性抗体的研究  

Classification of influenza A virus and its value for research of universal influenza vaccine and broad-spectrum neutralization antibody

作　　者：蒋露芳[1] 居丽雯[1] 姜庆五[1] 

机构地区：[1]复旦大学公共卫生学院卫生微生物教研室-公共卫生安全教育部重点实验室,上海200032

出　　处：《复旦学报（医学版）》2011年第6期476-480,共5页Fudan University Journal of Medical Sciences

基　　金：上海市重点学科建设项目(B118)

摘　　要：流感是对人类危害极大的传染病,疫苗接种被认为是预防流感的最有效手段。为解决流感病毒变异导致现有疫苗时效性与有效性的问题,研制能够预防所有流感病毒毒株、可诱导持久保护性免疫的通用流感疫苗一直是流感研究的热点,同时,能中和所有甲型流感病毒的广谱中和活性抗体的研究也已成为目前关注的重点,因此对甲型流感病毒分类研究也提出了相应的要求。Influenza is a great harm contagious disease for human.Vaccination is considered to be the most effective means to prevent influenza.For the problems of existing vaccine on timeliness and effectiveness,universal influenza vaccine,which can preclude all the influenza virus and induce duration protective immunity,has been a hot research.Meanwhile,the broad-spectrum neutralization antibody against all influenza A viruses is also the current focus.All these have made the request to explore applicable classification of influenza A virus.

关 键 词：甲型流感病毒 分类 通用流感疫苗 中和抗体 

分 类 号：R186[医药卫生—流行病学] R511.7[医药卫生—公共卫生与预防医学]