盐酸坦索罗辛胶囊联合消炎痛栓治疗慢性非细菌性前列腺炎  

Tamsulosin hydrochloride sustainedrelease capsule and indomethacin suppository treat chronic nonbacterial prostatitis

作　　者：董希智 牛健[1] 房刚[1] 王善刚[1] 路靖华 张秀芳[1] 孙辉[1] 

机构地区：[1]济南市长清区人民医院泌尿外科,山东济南250300

出　　处：《现代泌尿外科杂志》2011年第6期517-519,共3页Journal of Modern Urology

基　　金：吴阶平医学基金会资助(No.320675007140)

摘　　要：目的探讨口服α1-受体阻滞剂盐酸坦索罗辛缓释胶囊加直肠给药消炎痛栓对慢性非细菌性前列腺炎(CNP)的临床治疗效果。方法自2008年2月～2010年2月选择门诊CNP患者进行随机对照研究,实验组74例,口服盐酸坦索罗辛缓释胶囊联合直肠给药消炎痛栓;对照组72例,只口服盐酸坦索罗辛缓释胶囊,比较两组治疗效果。结果实验组治疗总有效率、症状减轻程度明显高于对照组,复发率明显低于对照组(P<0.05)。结论盐酸坦索罗辛缓释胶囊可缓解膀胱颈口的紧张度,降低后尿道阻力,减轻CNP引起的排尿困难症状;消炎痛栓直肠给药其有效成分可穿透组织到达前列腺炎症区域,缓解慢性炎症反应,减轻CNP所引起的疼痛和下尿路症状(LUTS)。Objective To evaluate the clinical efficacy of oral administration of α1-blocker tamsulosin hydrochloride sustained-release capsule combined with rectal administration of indomethacin suppository for chronic nonbacterial prostatitis （CNP）. Methods In a randomly control study we selected outpatients suffering from Clinic CNP Since Feb. 2008 to Feb. 2010 of all 146 patients. 74 who composed the study group underwent oral administration of α1-blocker tamsulosin hydrochloride sustained-release capsule in combination with rectal administration of indomethacin suppository, while 72 patients serving as controls underwent oral administration of tamsulosin sustained-release capsule only. Treatment efficacy was compared. Results Total effictive rate in the study group and the relieving of symptoms were significantly higher than that in the control group,and the recurrence rate was significantly lower （P〈0. 05）. Conclusions Tamsulosin hydrochloride sustained-release capsule can relieve the tension of the bladder neck, lower the resistance of posterior urethral and reduce the symptoms of dysuria caused by CNP, meanwhile rectal administration of indomethacin suppository can ease Chronic inflammation, relieve pain caused by CNP and the lower urinary tract symptoms （LUTS） ,with its active ingredients penetratiny the regional organizations and reaching the focus of prostatitis.

关 键 词：坦索罗辛 消炎痛栓 前列腺炎 

分 类 号：R697[医药卫生—泌尿科学]