Effects of electroacupuncture versus nimodipine on long-term potentiation and synaptophysin expression in a rat model of vascular dementia  

作　　者：Dengming Wei Xuemin Jia Xiangxu Yin Wenwen Jiang 

机构地区：[1]Department of Pathology, Medical School of Ningbo University, Ningbo 315211, Zhejiang Province, China

出　　处：《Neural Regeneration Research》2011年第30期2357-2361,共5页中国神经再生研究（英文版）

基　　金：the Natural Science Foundation of Zhejiang Province, No. Y208445; the Natural Science Foundation of Ningbo Science and Technology Bureau, No. 2009A610161; K.C. Wong Magna Fund from Ningbo University

摘　　要：The present study stimulated Baihui （DU 20） and Dazhui （DU 14） acupoints in a rat model of vascular dementia with electroacupuncture to investigate changes in long-term potentiation and synaptophysin expression in the hippocampus. The results revealed that synaptophysin expression in brain tissues was increased after electroacupuncture. After high4requency stimulation, the population spike latency was shortened and the excitatory postsynaptic potential slope and population spike amplitude were increased. In addition, cognitive function was enhanced, similar to the effects of intragastric perfusion of nimodipine. The results indicated that electroacupuncture at Baihui and Dazhui acupoints can improve learning and memory functions of a rat model of vascular dementia by promoting synaptophysin expression, enhancing hippocampal synaptic plasticity and accelerating synaptic transmission.The present study stimulated Baihui （DU 20） and Dazhui （DU 14） acupoints in a rat model of vascular dementia with electroacupuncture to investigate changes in long-term potentiation and synaptophysin expression in the hippocampus. The results revealed that synaptophysin expression in brain tissues was increased after electroacupuncture. After high4requency stimulation, the population spike latency was shortened and the excitatory postsynaptic potential slope and population spike amplitude were increased. In addition, cognitive function was enhanced, similar to the effects of intragastric perfusion of nimodipine. The results indicated that electroacupuncture at Baihui and Dazhui acupoints can improve learning and memory functions of a rat model of vascular dementia by promoting synaptophysin expression, enhancing hippocampal synaptic plasticity and accelerating synaptic transmission.

关 键 词：vascular dementia ELECTROACUPUNCTURE learning and memory ability long-term potentiation SYNAPTOPHYSIN neural regeneration 

分 类 号：Q749[生物学—分子生物学] Q427