肌肉萎缩与过氧化体增殖活化受体γ辅助活化因子1α的关系  

Relationship between muscular atrophy and peroxisome proliferator-activated receptor γ coactivator 1 alpha

作　　者：杨殊[1] 文野[1] 

机构地区：[1]国家体育总局湛江潜水运动学校,广东省湛江市524005

出　　处：《中国组织工程研究与临床康复》2011年第41期7775-7778,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:过氧化体增殖活化受体γ辅助活化因子1α(peroxisome proliferator-activated receptorγcoactivator1α,PGC-1α)能调节骨骼肌的功能,包括有:线粒体的生物发生、底物氧化和肌纤维类型等,最近还有研究发现PGC-1α能够预防肌肉的萎缩。目的:总结并讨论PGC-1α与肌肉萎缩之间的关系。方法:由第一作者用计算机检索中国期刊全文数据库(CNKI:2000/2010)和Medline数据库(2000/2010),关键词分别为"肌肉萎缩,PGC-1α,运动"和"muscle atrophy,PGC-1α,exercise"。共检索到56篇文章,按纳入和排除标准对文献进行筛选,共纳入22篇文章。从PGC-1α与肌肉萎缩、运动与PGC-1α共2个方面进行总结。结果与结论:PGC-1α表达增强能提高线粒体功能、人体的运动能力、降低氧化应激和抑制肌肉萎缩特异性基因的表达。说明运动可通过调节PGC-1α的表达来干预肌肉萎缩。BACKGROUND：Peroxisome proliferator-activated receptor γ coactivator 1 alpha（PGC-1α） can regulate numerous skeletal muscle functions including mitochondrial biogenesis,substrate oxidation,and muscle fibre type.Recently,PGC-1α has been found to prevent against muscular atrophy.OBJECTIVE：To summarize and discuss the relationship between PGC-1α and muscular atrophy.METHODS：A computer-based online retrieval of CNKI and Medline databases was performed by the first author to search papers published between 2000 and 2010 using the key words ＂muscle atrophy,PGC-1α,exercise＂ in Chinese or English.A total of 56 papers were retrieved.According to inclusion and exclusion criteria,22 papers were included in the final analysis.These papers were summarized from PGC-1α and muscular atrophy,and exercise and PGC-1α.RESULTS AND CONCLUSION：Enhanced PGC-1α expression can enhance mitochondrial function and human sport ability,reduce oxidative stress and inhibit the expression of muscular atrophy specific gene.Therefore,exercise may inhibit muscular atrophy by regulating PGC-1α expression.

关 键 词：过氧化体增殖活化受体γ辅助活化因子1α 肌肉萎缩 运动 氧化应激 组织工程 

分 类 号：R318[医药卫生—生物医学工程]