胶原蛋白/壳聚糖复合纳米纤维膜在生物医学工程中的应用  

Application of collagen/chitosan compound nanofiber membrane in biomedical engineering

作　　者：余丕军[1] 陈炜[1] 

机构地区：[1]江苏大学附属上海市第八人民医院整形外科,上海市200235

出　　处：《中国组织工程研究与临床康复》2011年第42期7897-7901,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家高技术研究发展计划(863计划)(2008AA03Z305)~~

摘　　要：背景:胶原蛋白-壳聚糖复合纳米纤维膜以其优异的力学性能和良好的组织细胞相容性而成为近年来科学研究的热点。目的:总结胶原蛋白/壳聚糖复合纳米纤维膜在生物医学工程中的应用进展。方法:以"胶原蛋白、壳聚糖、复合纳米纤维膜、胶原蛋白/壳聚糖复合纳米纤维膜、collagen/chitosan、compound Nanofiber membrane、collagen/chitosan compound nanofiber membrane、development of research" 为检索词,应用计算机检索Pubmed 数据库、Elsevier数据库、万方数据库1993-01/2010-05关于胶原蛋白/壳聚糖复合纳米纤维膜研究的相关文章,对53篇文献进行分析。结果与结论:研究表明,将胶原蛋白/壳聚糖共混,在不同条件下交联,其共混复合物在力学性能方面较单一的胶原蛋白有一定的改善,其共混膜可以作为较小软骨缺损的修复的支架材料。研究证实胶原蛋白/壳聚糖复合纳米纤维膜有着优异的力学性能、很好的组织细胞相容性和生物可降解性。文章从胶原蛋白和壳聚糖单一生物材料的缺陷性、复合纤维膜的优势及其在生物医药工程中的应用方面进行了探讨。BACKGROUND： Collagen/chitosan compound nanofiber membrane has become a research hotspot in recent years in respects of excellent mechanical properties and good biocompatibility. OBJECTIVE： To review the research progress of collagen/chitosan compound nanofiber membrane in biomedical engineering. METHODS： Literatures related to collogen/chitosan compound nanofiber membrane from PubMed database, Elsevier database and Wanfang database （1993-01/2010-05） were retrieved by computer with the Keywords of ＂collagen, chitosan, compound nanofiber membrane, collagen/chitosan compound nanofiber membrane＂ in Chinese and English According to inclusion criteria, 53 literatures were selected in this study. RESULTS AND CONCLUSION： The studies have demonstrated that collagen combined with chitosan crosslinked under different conditions, its compound had some improvement in mechanical properties of single collagen, and collagen/chitosan compound nanofiber membrane could be served as a small cartilage defect repair scaffold. It has been confirmed that collagen/chitosan compound nanofiber membrane has better mechanical properties, tissue cell compatibility and biodegradability. Collagen and defect of chitosan single material, advantages of compound nanofiber membrane and its application on biomedical engineering have been also discussed.

关 键 词：胶原蛋白 壳聚糖 胶原蛋白/壳聚糖复合纳米纤维膜 生物医学工程 综述文献 

分 类 号：R318[医药卫生—生物医学工程]