生物可降解心血管支架与人体相容性的系统评价  

Systematical evaluation for the biocompatibility of biodegradable cardiovascular stent materials

作　　者：黄成国[1] 袁萍[2] 董卫涛[3] 

机构地区：[1]贵州省人民医院干部医疗科,贵州省贵阳市550000 [2]重庆医科大学儿科学院,重庆市400020 [3]广州中医药大学,广东省广州市510006

出　　处：《中国组织工程研究与临床康复》2011年第42期7955-7959,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:冠状动脉支架置入后的再狭窄等并发症越来越引起关注。目的:系统评价生物可降解心血管支架材料与人体相容性的研究。方法:计算机检索EMbase(1980/2011-08)、MEDLINE(1966/2011-08)和中国生物医学文献数据库(CBM,1978/2011-08)、中文学术期刊全文数据库(CNKI),筛查相关文章的参考文献收集发表的生物可降解心血管支架生物相容性的动物实验和临床实验中文献,对可降解心血管支架材料生物相容性的总结。结果与结论:当血管内皮化完成之后,生物可降解支架如期降解,从而克服了支架本身作为异物的血栓源性,抑制早期血栓形成及晚期新生内膜增生,具有良好的生物相容性,有效降低了再狭窄的发生率。同时,生物可降解支架还可作为药物局部投放的载体,达到有效防止支架置入后血管急性闭塞和降低再狭窄发生率。BACKGROUND： Restenosis and other complications after coronary stent implantation have attracted more and more attention. OBJECTIVE： To systematically evaluate the biocompatibility of biodegradable cardiovascular stent materials. METHODS： A Computer-based online search of EMbase （1980/2011-08）, MEDLINE （1966/2011-12）, CBM （1978/2011-08） and CNKI for articles about animal experiments and clinical applications focusing on the biocompatibility of biodegradable cardiovascular stent materials. The included articles were generally analyzed to overall summarize the biocompatibility of biodegradable cardiovascular stent materials. RESULTS AND CONCLUSION： When the vascular endothelialization is complete, timely degradation of biodegradable stents overcomes thrombosis induced by the stent itself as a foreign body and inhibits early thrombosis and late neointimal hyperplasia, indicating that the stents have good biocompatibility and effectively reduce the restenosis incidence. Biodegradable stents can also be localized as a drug delivery carrier, to effectively prevent acute vascular occlusion and reduce the incidence of restenosis after stent implantation.

关 键 词：心血管支架 生物相容性 系统评价 可降解 紫杉醇 雷帕霉素 

分 类 号：R318[医药卫生—生物医学工程]