丹参注射液在肾移植后急慢性排斥反应中的作用  

Clinical application of salvia miltiorrhiza injection on the treatment of acute and chronic vascular rejection after renal transplantation

作　　者：陈夏[1] 蔡宪安[1] 周丽娟[2] 蔡腾[3] 

机构地区：[1]郑州市中心医院泌尿外科,河南省郑州市450007 [2]郑州市中心医院药剂科,河南省郑州市450007 [3]郑州大学医学院泌尿外科,河南省郑州市450052

出　　处：《中国组织工程研究与临床康复》2011年第44期8221-8224,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:临床观察,肾移植后发生急、慢性排斥反应时单用甲基强的松龙针冲击,尿蛋白、血肌酐值改善不明显,若加用丹参注射液静脉滴注,可使移植肾功能恢复更迅速。目的:观察丹参注射液对肾移植后急慢性排斥反应肾功能恢复的影响。方法:肾移植后发生急性排斥反应患者180例,慢性排斥反应患者140例,分别随机分成两组,对照组单纯应用常规甲基强的松龙冲击治疗3d,治疗组在此基础上加用丹参注射液静脉滴注15d。结果与结论:与治疗前相比,急慢性排斥反应两组肾功能恢复指标均有明显改善,差异有显著性意义(P<0.05);治疗组比对照组肾功能指标改善更明显(P<0.05)。且治疗组延长了凝血酶原时间和活化部分凝血活酶时间(P<0.05)。结果证实了肾移植患者发生急慢性排斥反应后在常规处理基础上加用丹参注射液能明显改善移植肾功能。BACKGROUND： Clinical observation shows that simple use of methylprednisolone （MP） to treatment acute and chronic vascular rejection after renal transplantation cannot obviously improve urine protein and serum creatinine levels and that salvia miltiorrhiza injection combined with MP can promote the functional recovery of transplanted kidney. OBJECTIVE： To investigate the effects of salvia miltiorrhiza injection on acute and chronic vascular rejection and renal function recovery after renal transplantation. METHODS： 180 cases with acute vascular rejection and 140 cases with chronic vascular rejection after renal transplantation were randomly divided into a control group and a treatment group. The control group patients were simply treated with routine MP for 3 days. The treatment group patients received MP administration for 3 days followed by intravenous administration of salvia miltiorrhiza injection for 15 days. RESULTS AND CONCLUSION： Compared with pretreatment, the indices of renal function were significantly improved in the control and treatment groups with acute and chronic vascular rejection （P 0.05）. The recovery of renal function was more obvious in the treatment group than in the control group （P 0.05）. Prothrombin time and activated partial thromboplastin time were significantly prolonged in the treatment group than in the control group （P 0.05）. Renal function was obviously improved after salvia miltiorrhiza injection was added based on conventional treatment in patients with acute and chronic vascular rejection after renal transplantation.

关 键 词：丹参注射液 肾移植 急性排斥反应 慢性排斥反应 肾功能 

分 类 号：R617[医药卫生—外科学]