Rh(D)血型不合的肝移植临床分析  

Clinical analysis of Rh (D) incompatibility in a liver transplantation patient

作　　者：尚丽明[1] 彭民浩[1] 覃晓[1] 郭雅[1] 肖开银[1] 彭涛[1] 

机构地区：[1]广西医科大学第一附属医院肝胆外科,广西壮族自治区南宁市530021

出　　处：《中国组织工程研究与临床康复》2011年第44期8337-8340,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广西医疗卫生重点科研基金项目(重201018)~~

摘　　要：背景:血型不合器官移植可能发生严重的排斥反应、移植物抗宿主病及溶血反应。目的:回顾分析Rh(D)阴性肝癌患者接受Rh(D)阳性供肝移植的方法及疗效,并结合文献复习探讨该方法的可行性。方法:1例Rh(D)阴性肝癌患者接受Rh(D)阳性供肝移植过程中,应保证供肝的良好灌洗,尽量减少出血,缩短手术时间,移植中移植后输注适量的异型红细胞及血浆。结果与结论:肝移植后,受者肝功能恢复正常,未发生急慢性排斥反应及输血相关并发症。随访1年,受者存活良好。说明在无合适供体的情况下,只要供肝得到充分灌洗、移植中控制出血、移植后采用合理的免疫抑制方案,Rh(D)阴性肝病患者移植Rh(D)阳性供肝可达到良好效果。BACKGROUND： Blood type incompatibility organ transplantation can result in severe rejection, graft versus host disease and hemolytic reaction. OBJECTIVE： To retrospectively analyze the liver transplantation method of RH（D）-negative patients with liver cancer using the RH （D）-positive donor and to investigate the feasibility of the method of transplantation based on related literatures. METHODS： One donor liver with Rh （D）-positive was transplanted to a patient of liver cancer with Rh （D）-negative. Then the donor liver with Rh （D）-positive was well lavaged, bleeding in operation should be minimized, and products of blood with Rh （D）-positive was infused. Follow-up and effects were observed. RESULTS AND CONCLUSION： One donor liver with Rh （D）-positive was successfully transplanted to a patient of liver cancer with Rh （D）-negative. The operation was smoothly performed. There were no acute and chronic rejection and blood transfusion-related complications after operation. The patient has survived for 1 year with normal liver function. These finding suggest that because there are no acute and chronic rejection and blood transfusion-related complications happened, so a donor liver with Rh （D）-positive can be transplanted into a patient with liver cancer with Rh （D）-negative blood after full irrigation and good clinical results have been acquired.

关 键 词：肝移植 Rh(D)血型系统 血型不合 器官移植 

分 类 号：R617[医药卫生—外科学]