慢性鼻窦炎手术前后血清和鼻腔分泌物中表皮生长因子水平变化  

Changes of EGF in serum and nasal fluid after endoscopic surgery in patients with chronic sinusitis

作　　者：王鹏举[1] 沈莹[1] 吴莉[1] 曹红[1] 李江平[1] 

机构地区：[1]襄樊市中心医院耳鼻咽喉头颈外科,湖北襄樊441021

出　　处：《中国耳鼻咽喉颅底外科杂志》2011年第5期366-370,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：湖北省科技攻关计划项目(2007AA402C27)

摘　　要：目的了解慢性鼻窦炎手术前后血清和鼻腔分泌物中表皮生长因子(epidermalgrowth factor,EGF)水平的变化,探讨EGF在鼻内镜术后术腔上皮过程中可能的作用。方法采用放射免疫方法检测慢性鼻窦炎手术患者术前及术后1、2、3、4、6、8周血清和鼻腔分泌物中EGF含量,并分析其变化规律。结果与正常对照比较,慢性鼻窦炎患者血清及鼻腔分泌物中EGF含量均升高,后者更为明显(P<0.0 5);术后第1周鼻腔分泌物中的EGF水平明显降低(P<0.05),第4周后开始升高;血清中EGF水平手术后呈缓慢下降,第6周后者开始上升。结论慢性鼻窦炎手术后血清和鼻腔分泌物中EGF水平存在一定归律的变化,这种变化模式与术后黏膜的转归以及创面修复有关,表明EGF术后鼻腔黏膜修复与上皮化过程中具有重要作用。Objective To evaluate the changes of epidermal growth factor（EGF） in the serum and nasal fluid after endoscopic surgery in patients with chronic sinusitis,and to explore the possible role of EGF in the postoperative epithelization of sinusal mucosa.Methods Serum and nasal fluid were collected at 1,2,3,4,6,and 8 weeks after functional endoscopic sinus surgery（FESS） and the EGF concentration was measured with radioimmunoassay.Results The EGF levels in the serum and nasal fluid in patients with chronic sinusitis were higher than those in the control group.The difference was statistically significant（P〈0.05） in the nasal fluid but insignificant（P〉0.05） in the serum.Compared with the preoperative levels of EGF,those at one week after FESS decreased significantly（P〈0.05）.The low concentration of EGF persisted for 3 weeks and then increased gradually in the nasal fluid,and that in the sersum tended to decrease slowly until 6 weeks after surgery.Conclusion The changes of EGF in the sersum and nasal fluid after endosocopic surgery may be related with the epithelization process of the sinusal mucosa after endoscopic surgery.

关 键 词：表皮生长因子 慢性鼻窦炎 鼻内镜术 

分 类 号：R765.4[医药卫生—耳鼻咽喉科] R34[医药卫生—临床医学]