乙型肝炎病毒相关性肾炎抗病毒治疗进展  

Antiviral Therapy of HBV Associated Glomerulonephritis

作　　者：王艳[1] 

机构地区：[1]北京大学第一医院感染疾病科,北京100034

出　　处：《医学与哲学（B）》2011年第11期12-14,共3页Medicine & Philosophy(B)

摘　　要：乙型肝炎病毒(HBV)相关性肾炎是与HBV感染相关的肾脏疾病,病理类型多为膜性肾病、膜增殖性肾小球肾炎等,临床表现常为肾病综合征或大量蛋白尿。由于发病机理尚不清楚,既往多采用激素等免疫抑制剂治疗,但临床效果不理想。由于该病和HBV感染有关,随着抗病毒药物治疗慢性乙型肝炎病毒感染取得较好疗效,已有研究应用干扰素、拉米夫定、恩替卡韦等抗病毒治疗乙型肝炎病毒相关性肾炎,初步显示可以使患者的蛋白尿减少或消失,肾功能得到改善。HBV--GN is a kind of kidney disease associated with HBV infection with the common pathogenesis of membra-nous nephropathy and membranoproliferative glomerulonephritis. The clinical manifestations include heavy proteinuria and the nephritic syndrome. Establishing the diagnosis is important because therapy with corticosteroids and cytotoxic agents may not be beneficial, and may be potentially dangerous. Antiviral agents should be used with appropriate dose adjustment for level of kidney function to improve clinical manifestations. Though the optimal duration of treatment is unclear, antiviral treatment is the key point to treat HBV--GN.

关 键 词：乙型肝炎病毒相关性肾炎 膜性肾病 膜增殖性肾小球肾炎 抗病毒治疗 

分 类 号：R512.62[医药卫生—内科学]