蓬子菜有效部位总黄酮的急性毒性实验研究  

Acute Toxicity of Total Flavonodis from the Effective Part of Galium Verum L

作　　者：崔明宇[1,2] 孙志伟[1,2] 王艳[1,2] 马英丽[1,2] 

机构地区：[1]黑龙江中医药大学 [2]黑龙江中医药大学北药基础与应用研究省部共建教育部重点实验室,黑龙江哈尔滨150040

出　　处：《中医药信息》2011年第6期36-37,共2页Information on Traditional Chinese Medicine

基　　金：哈尔滨市科技创新人才研究专项资金项目(2010RFXXS024);黑龙江中医药大学新药研究基金(X201001)

摘　　要：目的:对蓬子菜总黄酮安全性进行初步评价。方法:小鼠灌胃给药,通过预实验判断测定LD50的可能性,并据此测定LD50或MTD。结果:MTD测定结果显示,小鼠口服蓬子菜总黄酮最大耐受量相当于60kg体质量成人临床日用量的132倍。结论:蓬子菜总黄酮的急性毒性很小,安全性较高。Objective： To study the acute toxicity of total flavonodis of Galium verum L.in mice.Methods：A pretest was used to judge the possibility of LD50.The LD50 or Maximum tolerance dose（MTD） was measured by intragastric administration of the total flavonodis of Galium verum L.with the maximum concentration and maximum amounts in mice.Results： There were no dead mice in the pretest.LD50 could not be measured and MTD was needed.The MTD test showed that the MTD of mice was equal to 132 times of normal humans.Conclusion： No obvious acute toxicity is found from total flavonodis of Galium verum L.in mice,which has a high safety.

关 键 词：蓬子菜 总黄酮 急性毒性 LD50 最大耐受量 

分 类 号：R285.5[医药卫生—中药学]