大黄黄连泻心汤、理中丸对水浸应激型、幽门结扎型胃溃疡寒、热证模型大鼠血清COR含量的影响  

The Influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pill on COR Contents in Serum on Gastric Ulcer Induced by Bondage Water Immersion Stress or Pylorus Deligation Combined with Cold or Heat Syndrome Model Rats

作　　者：李冀[1] 李胜志[1] 柴剑波[1] 毕珺辉[1] 胡晓阳[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2011年第6期43-46,共4页Information on Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划项目(2006BAI08B04-03)

摘　　要：目的:探讨水浸应激型、幽门结扎型胃溃疡中医寒、热证模型的形成机制及寒、热方剂对胃溃疡寒、热证模型的基本作用机理并进一步探讨方证相应的客观规律。方法:采用寒、热因素结合束缚水浸、幽门结扎法应激法分别建立大鼠胃溃疡寒、热证动物模型,采用酶联免疫法检测各实验组受试大鼠血清COR的含量。结果:水浸应激型、幽门结扎型胃溃疡模型中除单寒组、寒假组外各模型组大鼠血清COR的含量与空白对照组比较均明显升高(P<0.05或P<0.01),以热因素表达明显,血清COR的含量可作为溃疡热证的微观指征。寒性方剂大黄黄连泻心汤可显著降低热性模型大鼠血清COR的含量(P<0.05或P<0.01);理中丸对其血清COR的含量影响不显著(P>0.05)。结论:通过"方证相应"理论验证了"病证结合"的胃溃疡寒、热模型复制成功,寒性方剂大黄黄连泻心汤对热性溃疡的治疗作用,可通过抑制大鼠血清皮质醇的分泌而实现。Objective：To explore the forming mechanism of gastric ulcer model induced by bondage water immersion stress or pylorus deligation combined with cold or heat syndrome.And to observe the basic mechanism of action of cold or heat formula on gastric ulcer model combined with cold or heat syndrome and the objective regularity of ＂formula-syndrome corresponding＂.Methods： Adopting cold or heat factors combined with bondage water immersion stress or pylorus deligation methods to establish gastric ulcer model combined with cold and heat syndrome.Using euzymelinked immunosorbent assay to detect the contents of COR in serum.Results：Compared with the blank group,except the cold syndrome group and the fake cold syndrome group,the contents of COR in serum increased remarkably in each model group,（P0.05 or P0.01）.The heat factors expressed obviously among the model groups,and the contents of COR could be regarded as the microscopic sign of heat-gastric ulcer.The cold prescription Dahuang Huanglian Xiexin Decoction could decrease the contents of COR of heat model groups.,（P0.05 or P0.01）.Conclusions：On the basis of the theory of ＂formula-syndrome corresponding＂,verifying the success of duplicating ＂disease-syndrome combination＂ model,that is gastric ulcer model combined with cold or heat syndrome.The therapeutic action of Dahuang Huanglian Xiexin Decoction on heat-gastric ulcer can be achieved by inhibiting the secrete of COR in serum.

关 键 词：大黄黄连泻心汤 理中丸 胃溃疡 寒、热证 皮质醇(COR) 

分 类 号：R285.5[医药卫生—中药学]