降脂饮对胰岛素抵抗大鼠脂肪因子的影响Ⅱ  

Influence of JZY on the Adipokine in Insulin Resistance Rats(Ⅱ)

作　　者：葛鹏玲[1] 韩东卫[1] 闫忠红[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2011年第6期104-105,共2页Information on Traditional Chinese Medicine

基　　金：黑龙江省中医药管理局项目(2006);黑龙江省教育厅项目(11521265);黑龙江省教育厅留学回国人员科技项目择优资助项目(2009);黑龙江省博士后科学基金(LBH-Z09001)

摘　　要：目的:观察降脂饮对胰岛素抵抗(Insulin Resistance,IR)大鼠血清抵抗素(Resistin)和脂肪指数的影响,探讨降脂饮改善胰岛素抵抗及代谢综合征的作用机制。方法:以高脂饲料喂养配合单次小剂量注射链脲佐菌素的方法复制胰岛素抵抗大鼠模型,造模成功后给予降脂饮进行干预,采用酶联免疫法检测血清中抵抗素(Resistin)水平,并计算脂肪指数。结果:降脂饮可降低血清Resistin水平及脂肪指数。结论:降脂饮可能通过降低血清Resistin水平和脂肪指数而改善胰岛素抵抗及代谢综合征。Objective：To observe the influence of JZY on the level of Resistin and Lipid index in insulin resistance（IR） rats,and to discuss the mechanism of JZY in ameliorating insulin resistance and metabolism syndrome.Method：1.We set up the IR model in rats by feeding them high fat diet combining with injecting small doses of STZ once to them.2.We use different doses of JZY to treat the IR rats compared with rosiglitazone.3.We observe the difference within each group on the side of insulin sensitivity and the level of Resistin and Lipid index.Result：Compared with blank group,remarkably Resistin and Lipid index ascend in model group;compared with model group,Resistin and Lipid index fall in JZY group.Conclusion：JZY can ameliorate IR by regulating the level of Resistin and Lipid index in IR rats.

关 键 词：胰岛素抵抗 降脂饮 抵抗素 脂肪指数 

分 类 号：R285.5[医药卫生—中药学]