基于动脉自旋标记技术的内侧颞叶癫痫病人脑血流灌注成像研究  

A Cerebral Blood Flow Perfusion Analysis in Patients with Temporal Lobe Epilepsy by Use of Arterial Spin Labeled Perfusion MR Imaging

作　　者：郭超[1] 郑罡[2,3] 陈春晓[1] 沈连芳[2] 张志强[2] 王利[2,3] 卢光明[1,2] 

机构地区：[1]南京航空航天大学自动化学院生物医学工程系,南京210006 [2]南京军区南京总医院影像科,南京210002 [3]南京航空航天大学民航学院民航工程系,南京210006

出　　处：《生物物理学报》2011年第11期975-983,共9页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(81101039;30470510;30800264);江苏省博士后基金项目(1002083c);南京军区重点医药卫生项目(07z030);南京军区南京总医院基金项目(Q2008063)~~

摘　　要：基于动脉自旋标记(arterial spin labeling,ASL)技术,分析内侧颞叶癫痫(mesialtemporal lobe epilepsy,mTLE)患者大脑血流灌注(perfusion)的改变情况。在静息态下,采集了30例内侧颞叶癫痫伴单侧海马硬化发作间期患者(其中左侧16例,右侧14例)及22例健康志愿者的ASL数据,并通过计算获取其相对脑血流量(relative CBF,rCBF)及灌注不对称率(asymmetric index,AI)。癫痫病人与正常人的比较结果表明:左侧mTLE患者在两侧海马旁回、梭状回、额叶、颞叶和患侧海马回及岛叶,右侧mTLE患者在两侧海马回、海马旁回、额叶、颞叶和患侧杏仁核及岛叶,rCBF均有所下降,且患侧的下降程度和范围均大于对侧。说明mTLE患者的海马硬化可能导致了痫灶区功能异常,并通过癫痫的发作影响到全脑。Using arterial spin labeling（ASL）,the authors have studied and analyzed the present of perfusion abnormalities in patients with mesial temporal lobe epilepsy（mTLE）.30 interictal patients with mTLE and hippocampal sclerosis（HS） including 16 patients with left mTLE（LTLE） and 14 patients with right mTLE（RTLE）,and 22 healthy volunteers underwent pulsed ASL（PASL） in resting state.Relative cerebral blood flow（rCBF） was calculated and compared using group analysis of statistic parameters mapping and perfusion asymmetric index of region of interest.The results demonstrated that compared to controls,the rCBF of epileptics decreased in bilateral parahippocampal,fusiform,frontal lobe,temporal lobe and ipsilateral insula,and hippocampus in patients with LTLE,bilateral hippocampus,parahippocampal,fusiform,frontal lobe and temporal lobe,and ipsilateral amygdale and insula in patients with RTLE,but decreasing degree and area in ipsilateral side was much more than contralateral side.This study provided evidences that the HS may cause functional abnormalities in seizure zones and influence the whole brain through seizures in patients with mTLE.

关 键 词：动脉自旋标记 磁共振成像 脑血流量 内侧颞叶癫痫 

分 类 号：R445.2[医药卫生—影像医学与核医学] R318[医药卫生—诊断学]