Synthesis of novel chiral N,P-containing multidentate ligands and their applications in asymmetric transfer hydrogenation  

作　　者：Shen Luan Yu Yan Yun Li Zhen Rong Dong Juan Ni Zhang Qi Li Jing Xing Gao 

机构地区：[1]State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green ChemicalProductions of Alcohols-Ethers-Esters and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

出　　处：《Chinese Chemical Letters》2011年第11期1269-1272,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos20423002 and 20703034);Natural Science Foundation of Fujian Province of China(No2008J0235) for the financial support of this work

摘　　要：Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.

关 键 词：Chiral multidentate aminophosphine ligand Iridium complex PROPIOPHENONE Asymmetric transfer hydrogenation 

分 类 号：O623.734[理学—有机化学] TQ463.53[理学—化学]