Synthesis,antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides  

作　　者：Davinder Kumar Archana Kapoor Ananda Thangadurai Pradeep Kumar Balasubramanian Narasimhan 

机构地区：[1]Department of Pharmaceutical Sciences Guru Jambheshwar University of Science and Technology,Hisar 125001,India [2]Department of Pharmaceutical Chemistry Swamy Vivekanandha College of Pharmacy,Tiruchengode 637205,India [3]Faculty of Pharmaceutical Sciences Maharshi Dayanand University,Rohtak 124001,India

出　　处：《Chinese Chemical Letters》2011年第11期1293-1296,共4页中国化学快报（英文版）

摘　　要：A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.

关 键 词：Benzylidene hydrazides SYNTHESIS ANTIMICROBIAL mt-QSAR LOO method 

分 类 号：TQ460.1[化学工程—制药化工]