老年高血压伴抑郁患者血浆肾素-血管紧张素Ⅱ-醛固酮的研究  

Study on Renin-angiotensin Ⅱ-aldosterone in the Elderly Hypertensive Patients with Depression

作　　者：宋文娟[1] 吴俊[1] 王璐[1] 

机构地区：[1]南京市市级机关医院神经科,210080

出　　处：《中国临床神经科学》2011年第6期621-625,共5页Chinese Journal of Clinical Neurosciences

基　　金：南京市卫生局资助课题(编号:YKK10187)

摘　　要：目的:探讨老年高血压合并抑郁患者血浆肾素-血管紧张素Ⅱ-醛固酮水平的变化与抑郁症、高血压病的关系。方法:原发性老年高血压病患者180例分为:高血压伴抑郁组(90例)、高血压组(90例),另设对照组(健康在校大学生90例),用放射免疫分析法测定血浆肾素-血管紧张素Ⅱ-醛固酮水平。结果:高血压伴抑郁组和高血压组血管紧张素Ⅱ均显著高于对照组(P<0.01);高血压伴抑郁组血管紧张素Ⅱ水平也显著高于高血压组(P<0.01)。高血压伴抑郁组和高血压组的肾素水平均显著低于对照组(分别P<0.05,P<0.01);高血压伴抑郁组肾素水平与高血压组比差异无统计学意义(P>0.05)。3组间血浆醛固酮水平无差异。高血压伴抑郁组的血浆血管紧张素Ⅱ水平与抑郁病程(r=0.412,P<0.01)和血压水平(r=0.369,P<0.01)呈一定正相关关系。结论:血管紧张素Ⅱ与老年高血压合并抑郁关系密切,血管紧张素Ⅱ可能参与了老年高血压合并抑郁的病理生理过程。Aim： To explore the changes of plasma renin-angiotensin Ⅱ-aldosterone levels in the elderly hypertensive patients with depression,and the relationship between renin-angiotensin Ⅱ-aldosterone and depression,hypertension.Methods： The plasma renin-angiotensin Ⅱ-aldosterone levels were measured by radioimmunoassay in elderly hypertensive patients with depression,elderly hypertensive patients and healthy controls.Results： The plasma angiotensin Ⅱ levels were significantly higher in elderly hypertensive patients with depression（P0.01）and elderly hypertensive patients（P0.01） than that in the controls.In addition,the plasma angiotensin Ⅱ level was significantly higher in elderly hypertensive patients with depression（P0.01） than that in elderly hypertensive patients.The plasma renin levels significantly decreased in elderly hypertensive patients with depression（P0.05） and in elderly hypertensive patients（P0.01） than that in the controls.There was no significant difference of the plasma renin level between elderly hypertensive patients with depression and elderly hypertensive patients.There was no significant difference of the plasma aldosterone levels betweeneach one of the three groups.The plasma angiotensin Ⅱ level had positive correlation with the duration of depression（r=0.412,P0.01）,the grade of hypertension（r=0.369,P0.01） in the elderly hypertensive patients with depression.Conclusion： There are confused phenomena among the changes of the plasma reninangiotensin II-aldosterone in the elderly hypertensive patients with depression.The angiotensin Ⅱ was closely related to the elderly hypertensive patients with depression.It suggested that the angiotensin Ⅱ might be involved in pathophysiology of the elderly hypertensive patients with depression.

关 键 词：老年高血压 抑郁 肾素 血管紧张素Ⅱ 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病] R749.13[医药卫生—内科学]