宫内拟除虫菊酯类农药暴露对1岁幼儿神经发育的影响  

Impact of prenatal pyrethroid exposure on neurodevelopment of one-year old infants

作　　者：齐小娟[1] 郑明岚[1] 邬春华[1] 常秀丽[1] 汪国权[2] 卢大胜[2] 周志俊[1] 

机构地区：[1]复旦大学公共卫生学院/公共卫生安全教育部重点实验室,上海200032 [2]上海市疾病预防控制中心

出　　处：《卫生研究》2011年第6期693-697,共5页Journal of Hygiene Research

基　　金：上海市公共卫生重点学科建设项目(No.08GWZX0303和08GWD20);复旦大学研究生创新基金(第10批)

摘　　要：目的检测某地孕妇尿液中拟除虫菊酯类农药代谢产物水平并跟踪随访幼儿1岁时神经智力发育水平,探讨宫内拟除虫菊酯暴露对1岁幼儿神经发育的影响。方法采集江苏省某妇产科医院301名孕妇产前尿液并检测其中拟除虫菊酯类农药主要代谢产物顺式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(cis-Cl2CA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(trans-Cl2CA)及3-苯氧基苯甲酸(3-PBA)水平;一年后随访测量1岁幼儿的身高、体重、头围、胸围等体格发育指标,并采用"0～6岁儿童发育筛查测验"(DST scale)对幼儿神经智力发育状况进行评估。结果 95%的孕妇尿中同时检出了三种拟除虫菊酯类农药代谢产物,且暴露水平高于国外相关数据;不同宫内拟除虫菊酯暴露水平之间幼儿1岁时神经智力发育水平有统计学差异,高暴露组幼儿的发育商显著低于低暴露组幼儿(P<0.05);多元线性回归的结果亦提示宫内拟除虫菊酯暴露水平与幼儿发育商之间存在联系(β=-0.1453,P<0.05)。结论宫内拟除虫菊酯类农药高暴露与幼儿神经智力水平发育之间存在负相关。Objective To investigate the impact of prenatal exposure to pyrethroid pesticides on neurodevelopment and behavior in a group of one-year old infants.Methods Three metabolites of pyrethroids（cis-Cl2CA、trans-Cl2CA and 3-PBA）in urine samples of 301 pregnant women enrolled from somewhere of Jiangsu Province were detected,The anthropometrics and the neurodevelopment of their 1-year old infants were assessed using DST scales.The mothers were consent informed before the study.Results Three metabolites of pyrethroid were detected in 95% of urine samples.The infants were divided into high,medium or low exposure group by the level of pyrethroid in their mothers＇ urine detected during pregnancy.The difference of neurodevelopment index（DQ） among three groups of one-year old children was significant（P0.05）,and the association of pyrethroid exposure with neurodevelopment was verified by multiple liner regression analysis（β=-0.1453,P0.05）.Conclusion Prenatal exposure to elevated levels of pyrethroid pesticides was associated with reduced neurodevelopment of infants in this population.

关 键 词：宫内暴露 拟除虫菊酯类农药 神经发育 

分 类 号：R139.3[医药卫生—劳动卫生] Q593.2[医药卫生—公共卫生与预防医学]