鱼腥草注射液与15种药物和3种输液的配伍稳定性研究  

Compatibility Stability of Yuxingcao Injection Mixed with Fifteen Drugs and Three Transfuses

作　　者：易艳[1] 梁爱华[1] 马珠凤 王治 李春英[1] 赵雍[1] 高双荣[1] 项琴 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]正大青春宝药业有限公司,杭州310023

出　　处：《中国实验方剂学杂志》2011年第23期36-39,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金(90709043);国家科技支撑计划项目(2006BAI14B05);国家科技重大专项(2009ZX09301-005);中国中医科学院自选课题(2008年度)

摘　　要：目的:探讨鱼腥草注射液与临床上常用的15种药物和3种输液配伍稳定性,为临床鱼腥草注射液的合理配伍用药提供参考。方法:按照临床配伍方式,将鱼腥草注射液与所选取的15种常用药物和3种输液进行配伍,测定配伍后10 min和2 h的外观、pH、不溶性微粒和鱼腥草素含量的变化。结果:鱼腥草注射液与更昔洛韦和维生素B1配伍后pH均超过了注射剂允许的范围,除了庆大霉素注射液、5%和10%葡萄糖注射液外,鱼腥草注射液与其他注射液配伍含10μm微粒数均超过药典规定,与左氧氟沙星、环丙沙星、庆大霉素、地塞米松和维生素C配伍后,鱼腥草素的含量下降均接近甚至超过10%。结论:鱼腥草注射液与5%和10%葡萄糖注射液无明显配伍禁忌,但应避免与5%葡萄糖盐水和上述15种药物配伍使用。Objective：To determine the compatibility stability of Yuxingcao injection mixed with fifteen drugs and three transfuses.Method：According to clinical compatibility,Yuxingcao injection was mixed with fifteen drugs and three transfuses,and then the appearance,the pH value,the insoluble particles and the content of decanoyl acetaldehyde in the mixed solution were detected.Result： The compatibility of Yuxingcao injection with Ganciclovir and vitamin B1 for injections was obviously changed in PH value;with all injections were significantly increased in insoluble particles except gentamicin injection,5% and 10% glucose injection transfuses,the content of decanoyl acetaldehyde with Levofloxacin,Ciprofloxacin,Gentamycin,Dexamethasone and vitamin C for injections were decreased about ten percent.Conclusion： Yuxingcao injection can be compatible with 5% and 10% glucose injection transfuses,it cannot be compatible with 5% glucose saline injection transfuses and fifteen drugs mentioned above.

关 键 词：鱼腥草注射液 药物 输液 配伍 

分 类 号：R284.1[医药卫生—中药学]