赤雹果乙醇提取物治疗子宫内膜炎继发痛经作用机制研究  

Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis

作　　者：李亚洲[1] 高冲[1] 胡晓丞[1] 佟继铭[1] 

机构地区：[1]承德医学院中药研究所,河北省中药研究与开发重点实验室,河北承德067000

出　　处：《中国实验方剂学杂志》2011年第23期148-150,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省自然科学基金项目(C200600863);河北省教育厅项目(2005225)

摘　　要：目的:探讨赤雹果乙醇提取物(AETF)治疗继发性痛经的机制。方法:采用植入塑料管法,制备大鼠子宫内膜炎继发性痛经模型。观察AETF对模型大鼠子宫组织匀浆中一氧化氮(NO)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性的影响。结果:AETF 0.3,0.6,1.2 g.kg-1剂量组子宫组织匀浆中NO的含量明显低于模型组(P<0.01),SOD的活性明显高于模型组(P<0.05);0.6,1.2 g.kg-1剂量组子宫匀浆中MDA的含量明显低于模型组(P<0.01),GSH-Px的活性显著高于模型组(P<0.05)。结论:AETF治疗继发性痛经作用机制与抑制致炎致痛介质的产生和促进过氧化物的清除有关。Objective：To investigate the mechanisms of the alcohol extract of Thladiantha dubia fruits（AETF） on secondary dysmenorrhea-induced endometritis.Method：The secondary dysmenorrhea model of endometritis was established by implanting the plastic tube into uterus.The effect of AETF on concentration of nitric oxide（NO） and malondialdehyde（MDA）,and the activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） in homogenate of uterus was observed by adopting the rats model.Result：AETF groups（0.3,0.6,1.2 g·kg-1） clearly decreased concentration of NO and increased activities of SOD,compared with model group（P0.01 and P0.05）;AETF groups（0.6,1.2 g·kg-1） clearly decreased concentration of MDA and increased activities of GSH-Px,compared with model group（P0.01 and P0.05）.Conclusion： The mechanisms of AETF on secondary dysmenorrhea may be related to the inhibition of inflammatory mediators and pianful mediators,the clearance of peroxides.

关 键 词：赤雹乙醇提取物 继发性痛经 一氧化氮 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 

分 类 号：R285.5[医药卫生—中药学]