升降方对应激大鼠胃排空及胃肠激素的影响  

Effect of Psychological Stress on Gastric Emptying and Gastrointestinal Hormones and the Preventive Effects of Shengjiang Fang in Rats

作　　者：徐伟[1] 孙维峰[1] 梁静[1] 张娴娴[1] 刘玲[1] 李丽[1] 

机构地区：[1]广州军区广州总医院中医科,广州510010

出　　处：《中国实验方剂学杂志》2011年第23期171-173,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省中医药局立项资助课题(2009286)

摘　　要：目的:探讨心理应激对大鼠胃排空及胃泌素(GAS)、胃动素(MOT)的影响及中药升降方的干预作用。方法:Wistar大鼠随机分成空白对照组、心理应激组、升降方高、低剂量(11.0,5.5 g.kg-1)加心理应激组。心理应激组给予复合应激,升降方高、低剂量组在心理应激组基础上分别给予升降方高、低剂量灌胃给药,15 d后测定各组大鼠胃排空及GAS,MOT的含量。结果:15 d后心理应激组大鼠的体重、胃排空率,GAS,MOT与空白对照组比较均明显下降(P<0.01或P<0.05);升降方高、低剂量(11.0,5.5 g.kg-1)加心理应激组的体重、胃排空率,GAS,MOT含量与心理应激组比较均明显升高(P<0.05)。结论:心理应激对大鼠胃排空有明显抑制作用,引起实验大鼠GAS和MOT水平下降,升降方可拮抗心理应激对大鼠胃排空的抑制,升高GAS和MOT水平。Objective：To study the effect of psychological stress on gastric emptying and gastrin（GAS）,motilin（MOT） in rats and the preventive effect of Shengjiang Fang.Method：Wistar rats were divided into 4 groups： control group,psychological stress group,psychological stress plus low dose of Shengjiang Fang 5.5 g·kg-1 and high-dose group（11.0 g·kg-1）,respectively.Gastric emptying ratios,GAS and MOT contents were measured.Result：Compared with the control group,the body weight,the gastric emptying ratio and GAS and MOT contents significantly decreased（P0.01 or P0.05） in psychological stress group.Compared with the psychological stress group,the body weight and the gastric emptying ratio and GAS and MOT contents both in psychological stress plus low and high-dose of Shengjiang Fang group were all increased（P0.05）.Conclusion：Psychological stress can decrease the gastric emptying rate and the GAS and MOT contents,Shengjiang Fang can antagonize the inhibitory effect of psychological stress on gastric emptying and increase the GAS and MOT contents in rats.

关 键 词：心理应激 升降方 胃排空 胃泌素 胃动素 

分 类 号：R285.5[医药卫生—中药学]