舒敏方对过敏和瘙痒模型的影响  

Influence of Shuminfang on Allergies and Itching Model

作　　者：张海娣[1] 董银卯[1] 孟宏[2] 

机构地区：[1]北京工商大学,北京100048 [2]中国中医科学院,北京100700

出　　处：《中国实验方剂学杂志》2011年第23期177-179,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:评价舒敏方对皮肤过敏和瘙痒的治疗作用。方法:以BALB/c小鼠和ICR小鼠为试验动物,研究8,4,2 g.kg-1(分别相当于临床剂量的2,1,0.5倍)舒敏方ig给药对受试动物的皮肤过敏和瘙痒的治疗作用。采用尾静脉iv伊文思蓝与sc磷酸组胺方法制作小鼠被动皮肤过敏模型、尾静脉iv右旋糖酐方法制作小鼠瘙痒模型,对舒敏方进行抗敏和抗瘙痒药效学试验。结果:与模型组比较,舒敏方高剂量组能缩小小鼠腹部皮肤蓝染的风团面积(P<0.05),抑制率为73.85%,高、中剂量组能有效抑制磷酸组胺所致小鼠皮肤毛细血管通透性亢进(P<0.01),抑制率分别为45.16%,41.94%;并能明显减少右旋糖酐诱发小鼠因皮肤瘙痒而搔抓的次数和缩短小鼠皮肤瘙痒持续时间(P<0.01)。结论:舒敏方对皮肤过敏和瘙痒有一定的改善作用。Objective：To evaluate Shuminfang influence on allergies and itching model.Method： The pharmacodynamic effects were observed in Passive cutaneous anaphylaxis by intravenous injection of Evans blue and subcutaneous injection of histamine phosphate,and itching model by intravenous injection of dextran in experimental animals.Result： Shuminfang high dose group can reduce the blue stained area of mice abdominal skin（P0.05）,the inhibition rate was 73.85%,high and middle dose group can inhibit the skin vascular permeability induced by histamine phosphate（P0.01）,the inhibition rates were 45.16%,41.94%;and can significantly reduce dextran-induced itching scratching number and shorten the duration（P0.01）.Conclusion： Shuminfang has certain effect on skin allergies and itching.

关 键 词：舒敏方 瘙痒模型 磷酸组胺 右旋糖酐 皮肤过敏 

分 类 号：R285.5[医药卫生—中药学]