冠心丹参片对高脂大鼠球囊损伤术后血管内膜增生的影响  

Effect of Guanxin Danshen Tablet on Neointimal Hyperplasia after Balloon Catheter Injury to the Common Carotid Artery of Rat with Hyperlipidemia of Guanxin Danshen Pellet

作　　者：罗颖颖[1] 陈兰英[1,2] 龚琴[1] 胡宏辉[1] 吴刚[2] 朱伟[2] 陈筱[1] 

机构地区：[1]中药固体制剂制造技术国家工程研究中心,南昌330006 [2]江西中医学院,南昌330004

出　　处：《中国实验方剂学杂志》2011年第23期203-206,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金："十一五"国家科技支撑计划项目(2006BAI08B03-05;2008BA151B03)

摘　　要：目的:观察冠心丹参片对高脂大鼠球囊损伤术后血管内膜增生的影响。方法:灌胃给予高脂乳剂30 d建立大鼠高脂血症,并在此基础上行大鼠左颈总动脉球囊损伤术,术后继续ig高脂乳剂14 d,造模同时开始分组给药:冠心丹参片高、中、低(含生药0.72,0.36,0.18 g.kg-1),阳性对照辛伐他汀4×10-3 g.kg-1,模型组和假手术组予生理盐水,均ig连续45 d。给药结束后检测血清中血脂水平,观察术后血管内膜增生情况,并计算内膜面积、中膜面积及内膜/中膜面积比。结果:冠心丹参片可以明显降低大鼠血清中总胆固醇(TC),甘油三酯(TG),低密度脂蛋白(LDL-C)水平,减少新生内膜面积,降低内膜/中膜面积比。结论:冠心丹参片具有抑制高脂大鼠球囊损伤术后血管内膜增生的作用。Objective：To study the effect of Guanxin Danshen tablet on balloon catheter injury to common carotid artery of rat with hyperlipidemia.Method： For induction of hyperlipidemia,high fat emulsion was offered to rats by intragastric administration once a day for 30 d,after that,balloon catheter injury to the left common carotid artery was performed.after ballon injury,the high fat diet was continously given for 14 d.Meanwhile,the animals in diferent groups were accordingly given Guanxin Danshen tablet（0.72,0.36,0.18 g·kg-1）,simvastatin（4×10-3 g·kg-1） and normal saline（for model and sham-operated group） for 45 d.levels of cholesterol,triglyceride,high density lipoprotein,low density lipoprotein in serum were detected,Neointimal hyperplasia was observed by HE staining,and neointimal area,media tunica area and ratio of neointimal area/media tunica area were caculated.Result： Guanxin Danshen tablet could lower the cholesterol,triglyceride and low density lipoprotein in serum of rats with hyperlipidemia,reduce the area of neointiaml and diminish the ratio of neointimal area/media tunica area.Conclusion： Guanxin Danshen tablet could suppress the neointimal hyperplasia after ballon catheter injury to the common carotid artery of rat with hyperlipidemia.

关 键 词：冠心丹参片 大鼠 高脂血症 颈动脉球囊损伤 内膜增生 动脉粥样硬化 

分 类 号：R285.5[医药卫生—中药学]