提高抗利尿激素分泌异常综合征的诊治水平  

The syndrome of inappropriate antidiuretic hormone secretion： the level on its diagnosis and treatment should be improved

作　　者：郭晓蕙[1] 董爱梅[1] 

机构地区：[1]北京大学第一医院内分泌科,100034

出　　处：《中华内分泌代谢杂志》2011年第11期873-875,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：抗利尿激素分泌异常综合征（SIADH）以稀释性低钠血症为主要表现，是住院患者等容量性低钠血症最常见的病因。SIADH的传统治疗包括限制液体人量、输注盐溶液及一些调节体液平衡的药物。由于各种原因，常规治疗的疗效欠佳。抗利尿激素受体拮抗剂是一种新型的药物，可以阻断抗利尿激素介导的受体活化，是针对SIADH的病因治疗。The syndrome of inappropriate antidiuretic hormone secretion （ SIADH）, characterized with dilutional hyponatremia, is the most frequent pathophysiology of euvolemic hyponatremia in hospital inpatients. Conventional therapies for SIADH include fluid resriction, saline infusion, and some pharmacologic adjustments of fluid balance. For various reasons, conventional therapies show poor efficiency. Vasopressin receptor antagonist, a new class of pharmacologic agent, can directly block vasopressin-mediated receptor activation and target underlying pathophysiology of SIADH.

关 键 词：抗利尿激素分泌异常综合征 低钠血症 抗利尿激素受体拮抗剂 

分 类 号：R58[医药卫生—内分泌]