IL-18作为疫苗佐剂的研究进展  

Research progress on IL-18 as a vaccine adjuvant

作　　者：张树菊[1] 冯其梅[1] 汪世平[1] 

机构地区：[1]中南大学湘雅医学院寄生虫学系,长沙410078

出　　处：《国际医学寄生虫病杂志》2011年第6期356-359,共4页International JOurnal of Medical Parasitic Diseases

基　　金：国家支撑计划重点项目（2009BA17805）资助

摘　　要：白细胞介素-18（IL-18）是一种免疫调节因子，具有多种生物学功能，能够刺激T细胞及NK细胞产生IFN-γ、IL-12等多种细胞因子，为增强Th1型细胞介导细胞免疫的细胞因子。该文对近年来IL-18作为免疫佐剂增强疫苗免疫效果的研究进行简要综述。Intreleukin-18 is one of immunity regulate cytokine that can stimulate T cells and NK cells to produce IFN-γ and IL-12 thus to enhance Thl type immunity. In recent years, many researches on IL-18 which as adjuvant can enhance the immunity reaction have been done. This article was mainly focused on the research progress on IL-18 as a vaccine adjuvant.

关 键 词：白细胞介素-18 免疫佐剂 疫苗 Th1型免疫 Th2型免疫 

分 类 号：R512.62[医药卫生—内科学]